Stanhope R, Abdulwahid N A, Adams J, Brook C G
Eur J Pediatr. 1986 Aug;145(3):190-4. doi: 10.1007/BF00446063.
We have studied the pulsatile secretion of gonadotrophins at night and made ovarian ultrasound examinations in three girls with central precocious puberty and three with isolated premature thelarche. The three girls with precocious puberty had well-defined pulsatile secretion of LH and FSH with LH predominating, as would be expected in normal puberty. Pulsatile secretion of gonadotrophins was also seen in girls with premature thelarche but the pattern was reversed. In girls with precocious puberty, large "multicystic" ovaries and large uteri were seen on ultrasound examination, whereas girls with isolated premature thelarche had small uteri and ovaries with less than four "cysts" up to 15 mm in diameter. These data provide the key to understanding the aetiology of isolated premature thelarche.
我们研究了夜间促性腺激素的脉冲式分泌情况，并对三名中枢性性早熟女童和三名单纯性乳房早发育女童进行了卵巢超声检查。三名性早熟女童的促黄体生成素（LH）和促卵泡生成素（FSH）呈现出明确的脉冲式分泌，且以LH为主导，这与正常青春期的情况相符。单纯性乳房早发育女童也出现了促性腺激素的脉冲式分泌，但模式相反。在性早熟女童中，超声检查可见大的“多囊性”卵巢和大子宫，而单纯性乳房早发育女童的子宫和卵巢较小，直径小于15毫米的“囊肿”不到四个。这些数据为理解单纯性乳房早发育的病因提供了关键线索。
