Segers Vincent F M, Gevaert Andreas B, Boen Jente R A, Van Craenenbroeck Emeline M, De Keulenaer Gilles W
Laboratory of Physiopharmacology, University of Antwerp , Antwerp , Belgium.
Department of Cardiology, University Hospital Antwerp, Edegem, Belgium.
Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1417-H1425. doi: 10.1152/ajpheart.00038.2019. Epub 2019 Apr 5.
The myocardium is a highly structured tissue consisting of different cell types including cardiomyocytes, endothelial cells, fibroblasts, smooth muscle cells, inflammatory cells, and stem cells. Microvascular endothelial cells are the most abundant cell type in the myocardium and play crucial roles during cardiac development, in normal adult myocardium, and during myocardial diseases such as heart failure. In the last decade, epigenetic changes have been described regulating cellular function in almost every cell type in the organism. Here, we review recent evidence on different epigenetic changes that regulate intercellular communication in normal myocardium and during myocardial diseases, including cardiac remodeling. Epigenetic changes influence many intercellular communication signaling systems, including the nitric oxide, angiotensin, and endothelin signaling systems. In this review, we go beyond discussing classic endothelial function (for instance nitric oxide secretion) and will discuss epigenetic regulation of intercellular communication.
心肌是一种结构高度复杂的组织，由不同类型的细胞组成，包括心肌细胞、内皮细胞、成纤维细胞、平滑肌细胞、炎症细胞和干细胞。微血管内皮细胞是心肌中数量最多的细胞类型，在心脏发育过程、正常成年心肌以及诸如心力衰竭等心肌疾病过程中发挥着关键作用。在过去十年中，已经有研究描述了表观遗传变化对机体几乎每种细胞类型的细胞功能的调控。在此，我们综述了关于不同表观遗传变化的最新证据，这些变化在正常心肌以及心肌疾病（包括心脏重塑）过程中调节细胞间通讯。表观遗传变化影响许多细胞间通讯信号系统，包括一氧化氮、血管紧张素和内皮素信号系统。在本综述中，我们不仅会讨论经典的内皮功能（例如一氧化氮分泌），还将探讨细胞间通讯的表观遗传调控。
