Department of Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT 06520, USA.
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Cell. 2019 Apr 4;177(2):223-224. doi: 10.1016/j.cell.2019.03.022.
A relationship between thermoregulation, metabolism, and the host response to infections has long been appreciated. In this study, Ganeshan and colleagues discover that the immune system regulates body temperature as a strategy to regulate metabolic rate, which in turn promotes tolerance to inflammatory damage.
体温调节、新陈代谢和宿主对感染的反应之间的关系早已被人们所认识。在这项研究中，Ganeshan 及其同事发现，免疫系统调节体温是一种调节代谢率的策略，而代谢率的调节又反过来促进了对炎症损伤的耐受。
