采用频域光学相干断层扫描测量原发性先天性青光眼患儿的视网膜神经纤维层厚度。
Retinal nerve fiber layer thickness in children with primary congenital glaucoma measured by spectral domain optical coherence tomography.
作者信息
Perucho-González Lucía, Martínez de la Casa José María, Sáenz-Francés Federico, Morales-Fernandez Laura, Méndez-Hernández Carmen Dora, Sánchez-Jean Rubén, García-Feijoó Julián
机构信息
Ophthalmology Service, Institute of Sanitary Research of the San Carlos Clinical Hospital, Madrid, Spain; Glaucoma Department, Institution of Sanitary Research of the San Carlos Clinical Hospital, Madrid, Spain.
Ophthalmology Service, Institute of Sanitary Research of the San Carlos Clinical Hospital, Madrid, Spain; Ocular Pathology, National Net OFTARED, Institute of Health Carlos III, University Hospital, Madrid, Spain; Glaucoma Department, Institution of Sanitary Research of the San Carlos Clinical Hospital, Madrid, Spain; Universidad Complutense, Madrid, Spain.
出版信息
J AAPOS. 2019 Apr;23(2):94.e1-94.e4. doi: 10.1016/j.jaapos.2017.03.023. Epub 2019 Apr 2.
PURPOSE
To evaluate retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) in a population of children diagnosed with primary congenital glaucoma (PCG).
METHODS
In this cross-sectional study, 59 eyes of 59 children diagnosed with PCG and 87 eyes of 87 healthy children were evaluated by SD-OCT to measure the RNFL. The global average peripapillary RNFL thickness and sectional RNFL thickness were evaluated in both groups. Differences in global average and sectional thickness were analyzed.
RESULTS
Mean age in the PCG group was 9.61 ± 3.23 years; in the control group, 8.47 ± 2.99 years (P = 0.0516). There were statistically significant differences (P < 0.007) in all sectors between both groups.
CONCLUSIONS
SD-OCT is a promising tool for evaluating the eyes of children diagnosed with PCG. Future research should examine the test-retest variability of SD-OCT parameters and their ability to diagnose progression in these children.
目的
使用光谱域光学相干断层扫描（SD-OCT）评估被诊断为原发性先天性青光眼（PCG）的儿童群体的视网膜神经纤维层（RNFL）厚度。
方法
在这项横断面研究中，通过SD-OCT对59例被诊断为PCG的儿童的59只眼和87例健康儿童的87只眼进行评估，以测量RNFL。对两组的视乳头周围RNFL厚度的总体平均值和各部分RNFL厚度进行评估。分析总体平均值和各部分厚度的差异。
结果
PCG组的平均年龄为9.61±3.23岁；对照组为8.47±2.99岁（P = 0.0516）。两组之间所有象限均存在统计学显著差异（P < 0.007）。
结论
SD-OCT是评估被诊断为PCG的儿童眼部情况的一种有前景的工具。未来的研究应检查SD-OCT参数的重测变异性及其诊断这些儿童病情进展的能力。
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