HBV 衣壳组装调节剂的最新进展。
Recent advances in the development of HBV capsid assembly modulators.
机构信息
Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, GA, 30322, United States.
Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, GA, 30322, United States.
出版信息
Curr Opin Chem Biol. 2019 Jun;50:73-79. doi: 10.1016/j.cbpa.2019.02.009. Epub 2019 Apr 2.
Hepatitis B virus (HBV) infections represent a significant burden on global public health. Current HBV treatments using nucleos(t)ide analogs (NAs) and PEG interferons cannot fully alleviate this burden as they do not affect the transcriptional activity of the tenacious covalently closed circular DNA (cccDNA) responsible for viral persistence. Capsid assembly modulators (CAMs) disrupt the encapsidation of pre-genomic RNA and can cause nucleocapsid disassembly, thereby affecting multiple steps of HBV replication and reduction of cccDNA pools. This review provides a concise overview of the development of CAMs and the progress achieved in understanding their interactions with HBV core proteins.
乙型肝炎病毒 (HBV) 感染对全球公共卫生造成了重大负担。目前使用核苷（酸）类似物 (NAs) 和聚乙二醇干扰素 (PEG 干扰素) 的 HBV 治疗方法不能完全减轻这种负担，因为它们不能影响负责病毒持续存在的顽强共价闭合环状 DNA (cccDNA) 的转录活性。衣壳组装调节剂 (CAMs) 可破坏前基因组 RNA 的包裹，并可导致核衣壳解体，从而影响 HBV 复制的多个步骤和 cccDNA 池的减少。本综述简要概述了 CAMs 的发展以及在理解其与 HBV 核心蛋白相互作用方面所取得的进展。
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