Gyllenhammar H, Ringertz B, Becker W, Svensson J, Palmblad J
Immunol Lett. 1986 Oct;13(4):185-9. doi: 10.1016/0165-2478(86)90053-2.
Linoleic and arachidonic acid concentrations in neutrophils from rats maintained on a diet with only 0.3% of the energy content as essential fatty acid (EFA, EFAD group) were reduced by 70 +/- 2.2% and 34.8 +/- 5.2%, respectively, compared with controls fed a diet with a normal 3% EFA content. Neutrophil chemiluminescence and aggregation induced by f-Met-Leu-Phe was substantially reduced in the EFAD group. Production of 6-keto-prostaglandin F1 alpha and thromboxane B2 were significantly lower in the EFAD neutrophils when stimulated by the ionophore A23187, whereas there was no difference when leukotriene B4 was used as stimulus.
与喂食正常含3%必需脂肪酸（EFA）饮食的对照组相比，仅以占能量含量0.3%的必需脂肪酸作为饮食的大鼠中性粒细胞中的亚油酸和花生四烯酸浓度分别降低了70±2.2%和34.8±5.2%。在必需脂肪酸缺乏（EFAD）组中，f-Met-Leu-Phe诱导的中性粒细胞化学发光和聚集显著降低。当用离子载体A23187刺激时，EFAD组中性粒细胞中6-酮-前列腺素F1α和血栓素B2的产生显著降低，而以白三烯B4作为刺激物时则没有差异。
