金催化炔烃氧化环氧化合成异苯并呋喃-4-酮和 2H-吡喃-3(6H)-酮。
Synthesis of isochroman-4-ones and 2H-pyran-3(6H)-ones by gold-catalyzed oxidative cycloalkoxylation of alkynes.
机构信息
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, Route de Saclay, 91128 Palaiseau, France.
Department of Chemistry and Biomolecular Sciences, University of Ottawa, K1N 6N5 Ottawa, Canada.
出版信息
Bioorg Med Chem. 2019 Jun 15;27(12):2616-2620. doi: 10.1016/j.bmc.2019.03.055. Epub 2019 Mar 30.
Gold catalysis is a convenient tool to oxidatively functionalize alkyne into a range of valuable compounds. In this article, we report a new access to isochroman-4-one and 2H-pyran-3(6H)-one derivatives that involves a gold-catalyzed oxidative cycloalkoxylation of an alkyne in the presence of a pyridine N-oxide. The reaction proceeds under mild conditions, is relatively efficient and exhibits a high functional group compatibility.
金催化是将炔烃氧化官能化生成一系列有价值化合物的便捷工具。在本文中，我们报告了一种新的异苯并呋喃-4-酮和 2H-吡喃-3(6H)-酮衍生物的合成方法，该方法涉及在吡啶 N-氧化物存在下，金催化炔烃的氧化环氧化反应。该反应在温和条件下进行，相对高效，并具有高官能团兼容性。
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