Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Chem Asian J. 2010 Apr 1;5(4):847-51. doi: 10.1002/asia.200900639.
The straightforward and efficient synthesis of naphtho[1,8-bc]pyran derivatives and related polycyclic compounds is achieved by the rhodium-catalyzed oxidative coupling of 1-naphthols or other phenolic and alcoholic substrates with alkynes. In these annulation reactions, the hydroxy groups effectively act as the key function for the regioselective C-H bond cleavage.
通过铑催化的 1-萘酚或其他酚类和醇类底物与炔烃的氧化偶联，实现了萘并[1,8-bc]吡喃衍生物及相关多环化合物的直接高效合成。在这些环化反应中，羟基作为关键官能团，实现了区域选择性的 C-H 键断裂。
