Department of Neurology, Division of Neuro-Epidemiology, New York University School of Medicine, New York, NY, USA; School of Public Health, City University of New York, New York, NY, USA.
Neurol Clin. 2019 May;37(2):399-423. doi: 10.1016/j.ncl.2019.01.014. Epub 2019 Mar 18.
The diagnosis of primary central and peripheral nerve vasculitides should be established with certainty if suspected before commencing potent immunosuppressive therapy. The aim of induction therapy is to rapidly control the underlying inflammatory response and stabilize the blood-brain and blood-nerve barriers, followed by maintenance immunosuppression tailored to the likeliest humoral and cell-mediated autoimmune inflammatory vasculitic processes.
如果怀疑存在原发性中枢和外周神经血管炎,应在开始使用强效免疫抑制剂治疗前明确诊断。诱导治疗的目的是迅速控制潜在的炎症反应,稳定血脑和血神经屏障,然后根据最有可能的体液和细胞介导的自身免疫性炎症性血管炎过程进行维持性免疫抑制治疗。