Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, South Korea.
Department of Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, South Korea.
Biochem Biophys Res Commun. 2019 May 21;513(1):201-206. doi: 10.1016/j.bbrc.2019.03.047. Epub 2019 Apr 2.
Elevated saturated free fatty acid levels during over-nutrition lead to hypothalamic inflammation, which perturbs energy homeostasis. Whether brain-derived metabolites are coupled to the development of obesity pathogenesis during the early over-nutrition period has not been thoroughly investigated. In this study, we found increased linoleic acid, an unsaturated fatty acid, in both the whole brain and hypothalamus of mice fed a high-fat diet for 4 weeks. Furthermore, we observed that linoleic acid effectively reversed the inflammatory responses induced by palmitic acid treatment in microglial cells. Collectively, this study suggests the reversible function of linoleic acid on brain inflammation in association with microglial activation during short-term exposure to a high-fat diet.
在营养过剩期间，升高的饱和游离脂肪酸水平会导致下丘脑炎症，从而扰乱能量平衡。在营养过剩的早期阶段，大脑衍生代谢物是否与肥胖发病机制的发展相关联，尚未得到彻底研究。在这项研究中，我们发现高脂饮食喂养 4 周的小鼠的全脑和下丘脑内，不饱和脂肪酸亚油酸的含量增加。此外，我们观察到亚油酸可有效逆转软脂酸处理诱导的小胶质细胞炎症反应。总的来说，这项研究表明，在短期暴露于高脂肪饮食期间，亚油酸对大脑炎症具有可逆作用，与小胶质细胞激活有关。
