γ干扰素对培养的小鼠腹腔巨噬细胞产生过氧化氢的影响。
Effect of gamma interferon on hydrogen peroxide production by cultured mouse peritoneal macrophages.
作者信息
Sharp A K, Banerjee D K
出版信息
Infect Immun. 1986 Nov;54(2):597-9. doi: 10.1128/iai.54.2.597-599.1986.
Abstract
Macrophage activation is thought to be mediated via a number of T-lymphocyte products, including gamma interferon (IFN-gamma). However, our studies indicate that IFN-gamma acts as a regulator molecule rather than solely as an activator. This depends upon the status of the macrophage. IFN-gamma treatment of resting macrophages and those activated or elicited by sodium caseinate, lipopolysaccharide, or Mycobacterium bovis BCG did not result in activation, as measured by hydrogen peroxide production; however, when thioglycolate was used as an eliciting agent, incubation with IFN-gamma resulted in a dramatic increase in hydrogen peroxide production compared with that by untreated controls.
摘要
巨噬细胞的激活被认为是通过多种T淋巴细胞产物介导的，包括γ干扰素（IFN-γ）。然而，我们的研究表明，IFN-γ作为一种调节分子发挥作用，而不仅仅是一种激活剂。这取决于巨噬细胞的状态。用IFN-γ处理静止的巨噬细胞以及那些由酪蛋白酸钠、脂多糖或牛分枝杆菌卡介苗激活或诱导的巨噬细胞，以过氧化氢产生量来衡量，并未导致激活；然而，当用巯基乙酸盐作为诱导剂时，与未处理的对照相比，与IFN-γ一起孵育会导致过氧化氢产生量显著增加。
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2
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J Immunol Methods. 1980;38(1-2):161-70. doi: 10.1016/0022-1759(80)90340-3.
3
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