神经丝轻链血清水平反映了与MOG抗体相关疾病的疾病严重程度。 - Suppr

Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders.

作者信息

Mariotto Sara, Ferrari Sergio, Gastaldi Matteo, Franciotta Diego, Sechi Elia, Capra Ruggero, Mancinelli Chiara, Schanda Kathrin, Alberti Daniela, Orlandi Riccardo, Bombardi Roberto, Zuliani Luigi, Zoccarato Marco, Benedetti Maria Donata, Tanel Raffaella, Calabria Francesca, Rossi Francesca, Pavone Antonino, Grazian Luisa, Sechi GianPietro, Batzu Lucia, Murdeu Noemi, Janes Francesco, Fetoni Vincenza, Fulitano Daniela, Stenta Gianola, Federle Lisa, Cantalupo Gaetano, Reindl Markus, Monaco Salvatore, Gajofatto Alberto

机构信息

Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy

Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy.

出版信息

J Neurol Neurosurg Psychiatry. 2019 Nov;90(11):1293-1296. doi: 10.1136/jnnp-2018-320287. Epub 2019 Apr 5.

DOI:10.1136/jnnp-2018-320287

PMID:30952681

Abstract

摘要

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Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders.神经丝轻链血清水平反映了与MOG抗体相关疾病的疾病严重程度。

J Neurol Neurosurg Psychiatry. 2019 Nov;90(11):1293-1296. doi: 10.1136/jnnp-2018-320287. Epub 2019 Apr 5.

Increased interleukin-6 correlates with myelin oligodendrocyte glycoprotein antibodies in pediatric monophasic demyelinating diseases and multiple sclerosis.在儿童单相脱髓鞘疾病和多发性硬化症中，白细胞介素-6升高与髓鞘少突胶质细胞糖蛋白抗体相关。

J Neuroimmunol. 2015 Dec 15;289:1-7. doi: 10.1016/j.jneuroim.2015.10.002. Epub 2015 Oct 8.

Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis.伴有髓鞘少突胶质细胞糖蛋白抗体、水通道蛋白4抗体的视神经炎与多发性硬化症的影像学鉴别

Mult Scler. 2016 Apr;22(4):470-82. doi: 10.1177/1352458515593406. Epub 2015 Jul 10.

Lower frequency of antibodies to MOG in Brazilian patients with demyelinating diseases: An ethnicity influence?巴西脱髓鞘疾病患者抗 MO G 抗体的频率较低：种族影响？

Mult Scler Relat Disord. 2018 Oct;25:87-94. doi: 10.1016/j.msard.2018.07.026. Epub 2018 Jul 17.

Myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies are highly specific in children with acquired demyelinating syndromes.髓鞘少突胶质细胞糖蛋白和水通道蛋白-4 抗体在获得性脱髓鞘综合征患儿中具有高度特异性。

Dev Med Child Neurol. 2018 Sep;60(9):958-962. doi: 10.1111/dmcn.13703. Epub 2018 Feb 22.

Serum and cerebrospinal fluid light neurofilaments and antibodies against them in clinically isolated syndrome and multiple sclerosis.血清和脑脊液中的神经丝轻链及针对它们的抗体在临床孤立综合征和多发性硬化中的研究。

J Neuroimmunol. 2013 Sep 15;262(1-2):113-20. doi: 10.1016/j.jneuroim.2013.06.010. Epub 2013 Jul 17.

Relevance of antibodies to myelin oligodendrocyte glycoprotein in CSF of seronegative cases.脑脊液中髓鞘少突胶质细胞糖蛋白抗体与血清阴性病例的相关性。

Neurology. 2019 Nov 12;93(20):e1867-e1872. doi: 10.1212/WNL.0000000000008479. Epub 2019 Oct 23.

Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis.多发性硬化症的蛋白质生物标志物：不同形式多发性硬化症脑脊液候选蛋白生物标志物的半定量分析。

Mult Scler. 2012 Aug;18(8):1081-91. doi: 10.1177/1352458511433303. Epub 2012 Jan 17.

Clinical and MRI phenotype of children with MOG antibodies.患有MOG抗体的儿童的临床和MRI表型

Mult Scler. 2016 Feb;22(2):174-84. doi: 10.1177/1352458515587751. Epub 2015 Jun 3.

Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease.中枢神经系统炎性脱髓鞘疾病患者脑脊液神经丝轻链增加。

Mult Scler Relat Disord. 2019 May;30:123-128. doi: 10.1016/j.msard.2019.02.009. Epub 2019 Feb 8.

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Complement Activation Profiles Predict Clinical Outcomes in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.补体激活谱可预测髓鞘少突胶质细胞糖蛋白抗体相关疾病的临床结局。

Neurol Neuroimmunol Neuroinflamm. 2025 Jan;12(1):e200340. doi: 10.1212/NXI.0000000000200340. Epub 2024 Dec 11.

NMOSD and MOGAD: an evolving disease spectrum.NMOSD 和 MOAD：一个不断演变的疾病谱。

Nat Rev Neurol. 2024 Oct;20(10):602-619. doi: 10.1038/s41582-024-01014-1. Epub 2024 Sep 13.

Serum NfL and EGFR/NfL ratio mRNAs as biomarkers for phenotype and disease severity of myelin oligodendrocyte glycoprotein IgG-associated disease.血清 NfL 和 EGFR/NfL 比值 mRNA 作为髓鞘少突胶质细胞糖蛋白 IgG 相关疾病表型和疾病严重程度的生物标志物。

Front Immunol. 2024 May 14;15:1388734. doi: 10.3389/fimmu.2024.1388734. eCollection 2024.

Neurofilaments as biomarkers in neurological disorders - towards clinical application.神经丝作为神经紊乱的生物标志物——迈向临床应用。

Nat Rev Neurol. 2024 May;20(5):269-287. doi: 10.1038/s41582-024-00955-x. Epub 2024 Apr 12.

Patterns of neuromyelitis optica spectrum disorder attacks in different age groups and sexes depending on the status of immunosuppressive therapy: A retrospective cohort study.基于免疫抑制治疗状况的不同年龄组和性别之间视神经脊髓炎谱系疾病发作模式：一项回顾性队列研究。

Eur J Neurol. 2024 Mar;31(3):e16178. doi: 10.1111/ene.16178. Epub 2023 Dec 20.

Initial BMI effects on clinical presentation and prognosis in neuromyelitis optica spectrum disorder.初诊 BMI 对视神经脊髓炎谱系疾病临床表现和预后的影响。

Ann Clin Transl Neurol. 2023 Sep;10(9):1673-1681. doi: 10.1002/acn3.51857. Epub 2023 Jul 26.

Visual disability in neuromyelitis optica spectrum disorders: prognostic prediction models.视神经脊髓炎谱系疾病的视力障碍：预后预测模型。

Front Immunol. 2023 Jun 7;14:1209323. doi: 10.3389/fimmu.2023.1209323. eCollection 2023.

Biomarkers in autoimmune diseases of the central nervous system.中枢神经系统自身免疫性疾病的生物标志物。

Front Immunol. 2023 Apr 5;14:1111719. doi: 10.3389/fimmu.2023.1111719. eCollection 2023.

Serum proteins for monitoring and predicting visual function in patients with recent optic neuritis.用于监测和预测近期视神经炎患者视觉功能的血清蛋白。

Sci Rep. 2023 Apr 5;13(1):5609. doi: 10.1038/s41598-023-32748-5.

Early blood neurofilament light chain and myelin oligodendrocyte glycoprotein antibody levels associate with different disease courses of myelin oligodendrocyte glycoprotein-associated disease in children.早期血神经丝轻链和髓鞘少突胶质细胞糖蛋白抗体水平与儿童髓鞘少突胶质细胞糖蛋白相关疾病的不同病程相关。

Brain Commun. 2023 Mar 15;5(2):fcad063. doi: 10.1093/braincomms/fcad063. eCollection 2023.

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Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders.

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