Charles University in Prague, First Faculty of Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Kateřinská 32, 121 08 Prague 2, Czech Republic.
J Neuroimmunol. 2013 Sep 15;262(1-2):113-20. doi: 10.1016/j.jneuroim.2013.06.010. Epub 2013 Jul 17.
A release of light neurofilament subunits (NFL) into cerebrospinal fluid (CSF) and serum in multiple sclerosis (MS) may induce an immune response. We examined CSF and serum NFL levels and IgG antibodies against NFL in 19 patients with a clinically isolated syndrome (CIS) early converted into MS, 20 CIS-non-converters, 23 MS patients and 32 controls. CSF NFL levels were significantly higher in all patient groups. The highest CSF or intrathecally (IT) synthesized anti-NFL antibodies and CSF/serum ratios of anti-NFL antibodies were observed in CIS-converters. CSF NFL and CSF or IT anti-NFL antibodies could be surrogate biomarkers of axonal injury in early MS.
神经丝轻链（NFL）在多发性硬化症（MS）患者的脑脊液（CSF）和血清中的释放可能会引发免疫反应。我们检测了 19 例临床孤立综合征（CIS）患者（早期转化为 MS）、20 例 CIS 非转化患者、23 例 MS 患者和 32 例对照者的 CSF 和血清中 NFL 水平和针对 NFL 的 IgG 抗体。所有患者组的 CSF NFL 水平均显著升高。CIS 转化者的 CSF 或鞘内（IT）合成的抗-NFL 抗体以及 CSF/血清抗-NFL 抗体比值最高。CSF NFL 和 CSF 或 IT 抗-NFL 抗体可能是早期 MS 轴突损伤的替代生物标志物。
