远端食管癌和胃食管交界癌手术后吻合口漏后的复发：一项系统评价
Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review.
作者信息
Aurello Paolo, Berardi Giammauro, Moschetta Giovanni, Cinquepalmi Matteo, Antolino Laura, Nigri Giuseppe, D'Angelo Francesco, Valabrega Stefano, Ramacciato Giovanni
机构信息
General Surgery Unit, Department of Medical and Surgical Sciences and Translational Medicine, St. Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
General Surgery Unit, Department of Medical and Surgical Sciences and Translational Medicine, St. Andrea University Hospital, Sapienza University of Rome, Rome, Italy
出版信息
Anticancer Res. 2019 Apr;39(4):1651-1660. doi: 10.21873/anticanres.13270.
BACKGROUND
Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease.
MATERIALS AND METHODS
A literature search was systematically performed. Seven out of 312 articles dated between 2009 and 2018 fulfilled the selection for a total of 5,433 patients.
RESULTS
The frequency of anastomotic leakage ranged from 7.2 to 11.2%. Patients affected by anastomotic leakage had a recurrence rate of 9-56%.
CONCLUSION
Closer follow-up or even more aggressive oncological therapy should be considered for patients affected by anastomotic leakage after surgery for carcinoma of the distal esophagus and gastroesophageal junction.
背景
食管癌是第九大常见癌症。唯一可能治愈的治疗方法是手术切除，但遗憾的是，手术仍会引发严重并发症，其中最重要的是吻合口漏，目前总体发病率高达26%。本系统评价的目的是评估吻合口漏与疾病复发之间的关系。
材料与方法
系统地进行文献检索。在2009年至2018年期间的312篇文章中，有7篇符合入选标准，共涉及5433例患者。
结果
吻合口漏的发生率在7.2%至11.2%之间。发生吻合口漏的患者复发率为9%至56%。
结论
对于远端食管癌和胃食管交界癌手术后发生吻合口漏的患者，应考虑进行更密切的随访，甚至采取更积极的肿瘤治疗。
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