限时进食可减轻高脂饮食增强的小鼠Lewis肺癌自发转移。
Time-restricted Feeding Attenuates High-fat Diet-enhanced Spontaneous Metastasis of Lewis Lung Carcinoma in Mice.
作者信息
Yan Lin, Sundaram Sneha, Mehus Aaron A, Picklo Matthew J
机构信息
U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, U.S.A.
出版信息
Anticancer Res. 2019 Apr;39(4):1739-1748. doi: 10.21873/anticanres.13280.
BACKGROUND/AIM: Obesity is a risk factor for cancer. Disruption of the daily feeding and fasting rhythm can contribute to obesity. This study tested the hypothesis that time-restricted feeding (TRF) attenuates obesity-enhanced metastasis.
MATERIALS AND METHODS
In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male C57BL/6 mice were fed the standard AIN93G diet or a high-fat diet (HFD) with or without dark-phase restricted feeding (12 h per day) for 10 weeks. Pulmonary metastases from a subcutaneous tumor were quantified.
RESULTS
The number and size of lung metastases were greater in the HFD group than in the AIN93G group, but did not differ between the TRF and AIN93G groups. TRF prevented HFD-induced increases in plasma concentrations of glucose, insulin, proinflammatory cytokines (leptin, monocyte chemotactic protein-1, plasminogen activator inhibitor-1), and angiogenic factors (angiopoietin-2, hepatic growth factor, vascular endothelial growth factor).
CONCLUSION
TRF attenuates the HFD-enhanced spontaneous metastasis of LLC in mice.
背景/目的：肥胖是癌症的一个风险因素。日常进食和禁食节律的紊乱会导致肥胖。本研究检验了限时进食（TRF）可减轻肥胖增强的转移这一假说。
材料与方法
在Lewis肺癌（LLC）自发转移模型中，雄性C57BL/6小鼠喂食标准AIN93G饮食或高脂饮食（HFD），有或没有黑暗期限时进食（每天12小时），持续10周。对皮下肿瘤的肺转移情况进行定量分析。
结果
HFD组肺转移灶的数量和大小均大于AIN93G组，但TRF组和AIN93G组之间无差异。TRF可防止HFD诱导的血浆葡萄糖、胰岛素、促炎细胞因子（瘦素、单核细胞趋化蛋白-1、纤溶酶原激活物抑制剂-1）和血管生成因子（血管生成素-2、肝细胞生长因子、血管内皮生长因子）浓度升高。
结论
TRF可减轻HFD增强的小鼠LLC自发转移。
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