Friedrich Reinhard E, Scheuer Hannah T
Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
Neurofibromatosis Laboratory Hamburg, Hamburg, Germany.
Anticancer Res. 2019 Apr;39(4):1971-1985. doi: 10.21873/anticanres.13308.
BACKGROUND/AIM: The purpose of the study was to investigate whether non-odontogenic intraosseous translucent lesions of mandibular body are depicted on radiographs of patients with neurofibromatosis type 1 (NF1).
The panoramic radiographs of 179 NF1 patients were analysed for translucent lesions of the mandibular body that were of intraosseous, non-odontogenic origin. The results were compared to findings obtained in panoramic radiographs of age- and sex-matched controls.
Only three patients showed intraosseous translucent lesions. These were always unilocular findings. There were no statistically significant differences between the groups (p=0.248).
Intraosseous neurofibroma of the jaw is a very rare finding in NF1 patients compared to oral neurofibromas. Accurate and exact diagnosis should be made in the case of such findings because malignant tumours in the jaw area can arise in rare cases in NF1 patients. Plain radiology findings cannot clearly indicate the type and biology of the lesion.
背景/目的：本研究旨在调查1型神经纤维瘤病（NF1）患者的下颌骨非牙源性骨内透光性病变在X线片上是否有显示。
分析179例NF1患者的全景X线片，以查找下颌骨骨内非牙源性起源的透光性病变。将结果与年龄和性别匹配的对照组全景X线片的检查结果进行比较。
仅3例患者显示骨内透光性病变。这些病变均为单房性。两组之间无统计学显著差异（p = 0.248）。
与口腔神经纤维瘤相比，颌骨骨内神经纤维瘤在NF1患者中是非常罕见的发现。对于此类发现应进行准确诊断，因为NF1患者颌骨区域在罕见情况下可能会出现恶性肿瘤。普通放射学检查结果不能明确显示病变的类型和生物学特性。
