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颌骨罕见的骨内肿胀:两例病例报告

An Unusual Intraosseous Swelling of the Jaw: Two Rare Case Reports.

作者信息

Jain Riya, Gosavi Suchitra, Sethia Deepak, Trimuke Akshay

机构信息

Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, CSMT-400001 Mumbai, Maharashtra India.

Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, Nagpur, Maharashtra India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):4032-4040. doi: 10.1007/s12070-023-04023-6. Epub 2023 Jul 4.

Abstract

Neurofibroma is the most common type of peripheral nerve neoplasm arising from a mixture of cell types, including schwann cells and perineurial fibroblasts. We report two unusual cases where patients presented with intraosseous swelling of the jaw. A complete examination followed by Imaging and histopathological examination were advised. Imaging showed ill-defined radiolucency in one case and well defined corticated radiolucency with soap-bubble appearance in the other case. Biopsy with adjuvant immunohistochemistry revealed features suggestive of neurofibroma. Both cases were managed surgically. The second case in the male patient, also showed multiple recurrences and subsequent transformation into atypical neurofibroma. In spite of being a benign tumor, neurofibroma is locally aggressive. Commonly found in soft tissues of the body, neurofibromas are rare in the head and neck region. But the intraosseous location of this tumor in the mandible is an exceptional case.

摘要

神经纤维瘤是最常见的周围神经肿瘤类型,由包括施万细胞和神经束膜成纤维细胞在内的多种细胞类型混合而成。我们报告了两例不寻常的病例,患者表现为颌骨骨内肿胀。建议进行全面检查,随后进行影像学和组织病理学检查。影像学检查显示,一例为边界不清的透射区,另一例为边界清晰的皮质透射区,呈肥皂泡样外观。活检及辅助免疫组化显示有神经纤维瘤的特征。两例均接受了手术治疗。男性患者的第二例还出现了多次复发,并随后转变为非典型神经纤维瘤。尽管神经纤维瘤是一种良性肿瘤,但具有局部侵袭性。神经纤维瘤常见于身体软组织,在头颈部区域较为罕见。但这种肿瘤在下颌骨的骨内位置是一个特殊病例。

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本文引用的文献

1
Prevalence of oral neurofibroma in Central Indian population: A retrospective study of 20 years.
J Oral Maxillofac Pathol. 2021 Jan-Apr;25(1):25-30. doi: 10.4103/jomfp.JOMFP_237_20. Epub 2021 May 14.
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