Madden Caitlin, Spector Adam, Siddiqui Sarwat, Mirkin Gene, Yim Joon, Hao Xingpei
Section of Podiatry, Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.
Laboratory of Pathology, Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.
Anticancer Res. 2019 Apr;39(4):2105-2111. doi: 10.21873/anticanres.13323.
Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-grade, dermal soft-tissue neoplasm with high recurrence, but low metastatic potential. It mainly occurs on the trunk, proximal extremity, head and neck, but rarely on the toes. Herein we report a case of DFSP on the right hallux.
A 39-year-old male presented with a mass in the right great toe of 3.5 years. After surgical excision, histopathological evaluation of the mass showed elongated monomorphic spindle cells arranged in a storiform pattern. The tumor cells infiltrated into adjacent adipose tissue in a honeycomb formation. Immunostaining for CD34 showed diffuse and strong cytoplasmic expression in neoplastic cells, whereas that for alpha smooth muscle actin, factor XIIIa, S-100 and melan-A were negative. The tumor was diagnosed as DFSP. We further reviewed the literature of DFSP on the toes with the aim to reveal, for the first time as far as we are aware, its clinical presentations, histopathology, differential diagnosis and treatment options.
DFSP on adult toes is a rare neoplasm characterized by monomorphic spindle cells arranged in storiform pattern, and can be treated with partial or total toe amputation, or wide local excision after primary excision, with excellent prognosis.
隆突性皮肤纤维肉瘤（DFSP）是一种罕见的、低级别真皮软组织肿瘤，具有高复发率，但转移潜能低。它主要发生于躯干、肢体近端、头颈部，而很少发生于脚趾。在此，我们报告一例发生于右拇趾的DFSP。
一名39岁男性，右拇趾肿物3.5年。手术切除后，肿物的组织病理学评估显示细长的单形性梭形细胞呈席纹状排列。肿瘤细胞呈蜂窝状浸润至相邻的脂肪组织。CD34免疫染色显示肿瘤细胞胞质弥漫性强表达，而α平滑肌肌动蛋白、因子ⅩⅢa、S-100和黑素A免疫染色均为阴性。该肿瘤被诊断为DFSP。我们进一步回顾了关于脚趾DFSP的文献，旨在首次揭示其临床表现、组织病理学、鉴别诊断及治疗选择。
成人脚趾的DFSP是一种罕见肿瘤，其特征为单形性梭形细胞呈席纹状排列，可采用部分或全部截趾治疗，或在初次切除后进行广泛局部切除，预后良好。
