Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
BMC Pregnancy Childbirth. 2019 Apr 5;19(1):118. doi: 10.1186/s12884-019-2267-x.
Pregnant women infected with brucellosis have been shown to have higher odds of having been exposed to goats and raw goat products and adverse pregnancy outcomes. However, information on these associations in asymptomatic pregnant women is limited, particularly in the brucellosis-endemic areas. This study aimed to assess the association of a history of exposure to goats and/or raw goat products and the serological status of anti-Brucella abortus immunoglobulin G (IgG) with adverse pregnancy outcomes among pregnant women, and explore factors associated with having exposure to goats and/or raw goat products.
A prospective cohort study was conducted among pregnant women from July 2015 to July 2016 at Songkhla province in southern Thailand. All pregnant women who came for antenatal care (ANC) visits were approached. Blood samples from the women who agreed to participate were randomly tested for anti-Brucella abortus IgG. The women were then followed for adverse pregnancy outcomes.
Of 666 pregnant women, the majority (74.4%) were aged 20-34 years and Muslim (89.2%), 30.6% indicated exposure to goats or raw goat products, and 17.3% had adverse pregnancy outcomes. Women rearing goats at home or having neighbors rearing goats were more likely to be exposed to goats or raw goat products by cutaneous contact. Of 465 women having a blood test, 3.7% had seropositive results for anti-Brucella abortus IgG. No association with adverse pregnancy outcomes was found in the women reporting any exposure to goat and raw goat products. Having the first ANC visit at the first trimester and history of preterm birth or low birth weight newborn were independent risk factors of adverse pregnancy outcomes. Women who had positive serological results were more likely to have a history of drinking raw goat milk than those who had negative results significantly.
Although no association between past exposure with goats and raw goat products and adverse pregnancy outcomes was found, women with past exposure showed positive anti-Brucella abortus IgG. Counseling on avoiding consumption of raw goat milk would be beneficial to prevent goat-related infection in pregnant women in this area.
已有研究表明，感染布鲁氏菌病的孕妇与接触山羊和生羊奶产品以及不良妊娠结局的可能性更高有关。然而，在无症状孕妇中，有关这些关联的信息有限，特别是在布鲁氏菌病流行地区。本研究旨在评估接触山羊和/或生羊奶产品的历史以及抗布鲁氏菌 abortus 免疫球蛋白 G（IgG）的血清学状态与孕妇不良妊娠结局之间的关系，并探讨与接触山羊和/或生羊奶产品相关的因素。
2015 年 7 月至 2016 年 7 月在泰国南部宋卡省进行了一项前瞻性队列研究。所有来进行产前保健（ANC）就诊的孕妇都被接触。同意参加的孕妇随机抽取血液样本进行抗布鲁氏菌 abortus IgG 检测。然后对这些孕妇进行不良妊娠结局随访。
在 666 名孕妇中，大多数（74.4%）年龄在 20-34 岁之间，且为穆斯林（89.2%），30.6%的孕妇表示接触过山羊或生羊奶产品，17.3%的孕妇出现不良妊娠结局。在家中饲养山羊或有邻居饲养山羊的孕妇更有可能通过皮肤接触接触到山羊或生羊奶产品。在 465 名接受血液检查的孕妇中，有 3.7%的孕妇抗布鲁氏菌 abortus IgG 血清学检测结果呈阳性。报告有任何接触山羊和生羊奶产品的孕妇与不良妊娠结局之间没有关联。首次 ANC 检查在孕早期，以及有早产或低出生体重新生儿史是不良妊娠结局的独立危险因素。血清学检测结果阳性的孕妇比阴性的孕妇更有可能有饮用生羊奶的病史。
尽管没有发现过去接触山羊和生羊奶产品与不良妊娠结局之间存在关联，但有过去接触史的孕妇表现出抗布鲁氏菌 abortus IgG 阳性。在该地区，建议孕妇避免饮用生羊奶，这将有利于预防与山羊相关的感染。
