Christian Hospital Quakenbrück, Academic Teaching Hospital of the University of Oldenburg, 49610 Quakenbrück, Germany.
J Neurol Sci. 2019 May 15;400:148-152. doi: 10.1016/j.jns.2019.03.028. Epub 2019 Mar 29.
Pilocytic astrocytoma (PA) is a neurological neoplasm and a common neurological tumor among children. No recent reports have studied the recent demographic characteristics of PA cases in the US.
We used the Surveillance, Epidemiology, and End Results (SEER) Program to retrieve data on children diagnosed with PA between 2000 and 2015. We calculated the incidence, annual percentage changes (APC), and survival.
Our study included 3084 children with PA, with an incidence of 8.227 per 1,000,000 person-years, being highest among whites (9.062), and children aged 1-4 year (11.175). Overall incidence in children increased significantly over the study period, with an APC of 0.825% (95% CI[0.027-1.630], P = .044). Moreover, incidence among blacks increased significantly over the study period (APC = 3.466%, 95% CI[0.342-6.688], P = .032), but did not change among other races. The relative 5-year survival of included patients was 95.3%, with patients younger than 1 year having the worst survival.
Overall PA incidence and incidence among blacks has been increasing last decade. Additionally, PA survival was found to be worse among infants. Further studies are also needed to investigate the effect of the age and race on the incidence and survival of PA.
毛细胞型星形细胞瘤（PA）是一种神经肿瘤，也是儿童常见的神经肿瘤。目前尚无研究报告分析美国近期 PA 病例的人口统计学特征。
我们使用监测、流行病学和最终结果（SEER）计划检索了 2000 年至 2015 年间诊断为 PA 的儿童病例数据。我们计算了发病率、年百分比变化（APC）和生存率。
我们的研究纳入了 3084 例 PA 患儿，发病率为 8.227/100 万，其中白人发病率最高（9.062/100 万），年龄在 1-4 岁的患儿发病率最高（11.175/100 万）。研究期间，儿童 PA 总发病率呈显著上升趋势，APC 为 0.825%（95%CI[0.027-1.630]，P=0.044）。此外，研究期间黑人的发病率呈显著上升趋势（APC=3.466%，95%CI[0.342-6.688]，P=0.032），而其他种族的发病率没有变化。纳入患者的 5 年相对生存率为 95.3%，1 岁以下患者的生存率最差。
过去十年中，PA 的总体发病率和黑人发病率呈上升趋势。此外，婴儿的 PA 生存率较差。还需要进一步研究以探讨年龄和种族对 PA 发病率和生存率的影响。
