School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China.
School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China.
J Affect Disord. 2019 Jun 1;252:1-8. doi: 10.1016/j.jad.2019.03.084. Epub 2019 Mar 30.
Burnout is a worked-related stress syndrome caused by long-term exposure to a stressful environment. Dysregulation of the hypothalamic- pituitary- adrenal (HPA) axis may be involved in both stress and burnout; an evaluation of genetic polymorphisms which alter activity in the HPA may be predictive of how likely an environment is to produce burnout.
Using a cross-sectional design, this study examined whether corticotrophin-releasing hormone receptor 1 (CRHR1) gene polymorphism rs110402 is a risk factor for burnout; further, it explores whether the interaction of stress × CRHR1 gene predicts burnout in the healthcare workers in a Chinese Han population. House and Rizzo's work stress scale, Sources of Pressure Scale and Maslach Burnout Inventory-General Survey were administered to 712 participants from a large general hospital in Beijing. The CRHR1 rs110402 polymorphism was genotyped in 376 participants.
Our results showed significant positive inter-correlations between stressor, work stress and depressive scores (all p < 0.001) with only one exception. Males, younger age and higher educational level were associated with burnout (all p < 0.05). The presence of the CRHR1 rs110402 genotype was not correlated with the presence of job stress or burnout. However, we found statistically significant interaction between CRHR1 rs110402 and job stress on burnout (p < 0.05). Individuals homozygous for the A allele reported significantly higher emotional exhaustion than G allele carriers in the high stress group.
The sample was only chosen from the medical professions, and the sample size was relatively small. Only one polymorphism in CRHR1 gene was analyzed, while only about half of the total individuals were genotyped.
Our results suggest a close relationship between work-related stress and burnout and that the A allele of the CRHR1 rs110402 polymorphism may enhance feelings of emotional exhaustion when experiencing work-related stress.
burnout 是一种与工作相关的压力综合征，由长期暴露于压力环境引起。下丘脑-垂体-肾上腺（HPA）轴的失调可能与应激和 burnout 都有关；评估改变 HPA 活性的遗传多态性可能可以预测环境产生 burnout 的可能性。
使用横断面设计，本研究检查了促肾上腺皮质释放激素受体 1（CRHR1）基因多态性 rs110402 是否是 burnout 的危险因素；进一步探讨了在中国汉族人群中，应激与 CRHR1 基因的相互作用是否预测医护人员的 burnout。对来自北京一家大型综合医院的 712 名参与者进行了 House 和 Rizzo 工作压力量表、压力源量表和 Maslach 职业倦怠量表的评估。在 376 名参与者中对 CRHR1 rs110402 多态性进行了基因分型。
我们的结果显示，应激源、工作压力和抑郁评分之间存在显著的正相关（均 p<0.001），但有一个例外。男性、年龄较小和较高的教育水平与 burnout 相关（均 p<0.05）。CRHR1 rs110402 基因型与工作压力或 burnout 无关。然而，我们发现 CRHR1 rs110402 与工作压力对 burnout 的交互作用具有统计学意义（p<0.05）。在高应激组中，A 等位基因纯合的个体报告的情绪衰竭明显高于 G 等位基因携带者。
样本仅从医疗行业中选择，样本量相对较小。仅分析了 CRHR1 基因的一个多态性，而只有大约一半的个体进行了基因分型。
我们的结果表明，工作相关的压力与 burnout 密切相关，CRHR1 rs110402 多态性的 A 等位基因在经历工作相关压力时可能会增强情绪衰竭的感觉。
