He Shu-Chang, Wu Shuang, Wang Chao, Wang Dong-Mei, Wang Jiesi, Xu Hang, Wang Li, Zhang Xiang Yang
School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, 5 Yiheyuan Road, Haidian district, 100871 Beijing, China.
School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, 5 Yiheyuan Road, Haidian district, 100871 Beijing, China.
J Affect Disord. 2020 Apr 1;266:671-677. doi: 10.1016/j.jad.2020.01.181. Epub 2020 Feb 1.
Some studies have shown that long-term exposure to job stress could result in burnout, and BDNF polymorphism may play an important role in its psychopathological mechanism. However, the inter-relationships between the job-related stress, serum BDNF level, BDNF genotype and job burnout have not been examined. This study was to explore the job stress × BDNF rs2049046 interaction and the role of serum BDNF level in job burnout in a Chinese Han population.
Using a cross-sectional design, 205 healthy subjects were recruited from a public institution in Beijing and assessed for job stress using the House and Rizzo's Work Stress Scale, and job burnout using the Maslach Burnout Inventory (MBI). The BDNF rs2049046 polymorphism was genotyped and serum BDNF (sBDNF) levels were assayed in all of subjects.
The correlations between the job stress score and two burnout subscale scores (emotional exhaustion and cynicism) were significant (both p < 0.001), but not with professional efficacy. There were no significant main effects of the BDNF rs2049046 genotype on burnout, and no significant correlation was observed between sBDNF levels and job burnout. However, the interaction between the job stress and the BDNF rs2049046 genotype (F = 2.709, df = 2, 183, p = 0.032) or between the job stress and sBDNF levels on burnout was significant (t = -2.132, p = 0.035). To be specific, the individuals with the BDNF rs2049046 AT genotype showed a greater susceptibility to the burnout cynicism compared to AA homozygote only in medium-stress group (F = 4.327, df = 1,117, p = 0.015). The individuals who had lower sBDNF showed higher burnout level than those who had higher sBDNF in low-stress group.
Our findings suggest that the BDNF system may interact with job stress to affect burnout, showing that interaction between BDNF rs2049046 and job stress or the interaction between BDNF levels with work stress on certain burnout dimensions.
一些研究表明，长期暴露于工作压力可能导致倦怠，而脑源性神经营养因子（BDNF）多态性可能在其心理病理机制中起重要作用。然而，工作相关压力、血清BDNF水平、BDNF基因型与工作倦怠之间的相互关系尚未得到研究。本研究旨在探讨中国汉族人群中工作压力×BDNF rs2049046的相互作用以及血清BDNF水平在工作倦怠中的作用。
采用横断面设计，从北京某事业单位招募205名健康受试者，使用豪斯和里佐的工作压力量表评估工作压力，使用马氏工作倦怠量表（MBI）评估工作倦怠。对所有受试者进行BDNF rs2049046多态性基因分型并检测血清BDNF（sBDNF）水平。
工作压力得分与两个倦怠分量表得分（情感耗竭和玩世不恭）之间存在显著相关性（均p<0.001），但与专业效能无关。BDNF rs2049046基因型对倦怠无显著主效应，sBDNF水平与工作倦怠之间未观察到显著相关性。然而，工作压力与BDNF rs2049046基因型之间的相互作用（F=2.709，自由度=2,183，p=0.032）或工作压力与sBDNF水平之间对倦怠的相互作用显著（t=-2.132，p=0.035）。具体而言，仅在中等压力组中，BDNF rs2049046 AT基因型个体比AA纯合子个体对玩世不恭倦怠更敏感（F=4.327，自由度=1,117，p=0.015）。在低压力组中，sBDNF水平较低的个体比sBDNF水平较高的个体倦怠水平更高。
我们的研究结果表明，BDNF系统可能与工作压力相互作用以影响倦怠，表明BDNF rs2049046与工作压力之间的相互作用或BDNF水平与工作压力在某些倦怠维度上的相互作用。
