Center of Hematology, Key Laboratory of Tumor Immunotherapy of Chongqing, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China.
College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China.
Chem Biol Interact. 2019 Jun 1;306:29-38. doi: 10.1016/j.cbi.2019.04.001. Epub 2019 Apr 5.
Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has various pharmacological effects, such as antioxidation, anti-aging, anti-inflammation, anti-cancer, antiobesity, anti-diabetes, cardioprotection, neuroprotection. Recently, anti-leukemia activities of resveratrol has been studied extensively via its effects on a variety of biological processes involving cell proliferation, apoptosis, autophagy. Current treatments of leukemia mainly rely on intensive chemotherapy or hematopoietic stem cell transplantation, however, these treatments are still with poor survival and high treatment-related mortality. Therefore, it is extremely needed to find relatively non-toxic medicines with minimal side effects but sufficient therapeutic efficacy. Resveratrol is one such potential candidate owing to its reported anti-leukemia effect. In this review, we summarized resveratrol's discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resveratrol as a potential drug candidate for anti-leukemia.
白藜芦醇是一种天然的芪类多酚，存在于多种植物中。它具有多种药理作用，如抗氧化、抗衰老、抗炎、抗癌、抗肥胖、抗糖尿病、心脏保护、神经保护。最近，通过研究白藜芦醇对涉及细胞增殖、凋亡、自噬等多种生物过程的影响，广泛研究了其抗白血病活性。目前白血病的主要治疗方法依赖于强化化疗或造血干细胞移植，但这些治疗方法的生存率仍然较低，治疗相关死亡率较高。因此，迫切需要寻找相对无毒、副作用小但疗效足够的药物。白藜芦醇是一种具有潜在治疗作用的候选药物，因为它具有抗白血病作用。在这篇综述中，我们总结了白藜芦醇的发现、来源和分离方法、给药方法、在不同类型白血病中的作用、药代动力学和毒性，旨在将白藜芦醇开发为一种潜在的抗白血病药物候选物。
