Tsan Min-Fu, White Julie E, Maheshwari Jewraj G, Chikkappa G
Office of Research Compliance and Assurance, Department of Veterans Affairs, Washington, DC 20422, USA.
Leuk Lymphoma. 2002 May;43(5):983-7. doi: 10.1080/10428190290021669.
Resveratrol is a phytoalexin naturally present in fruits, medicinal plants and wines. It has a diversity of biological activities. While its role in the protection against coronary heart disease (CHD) in people with moderate wine consumption, remains unclear, resveratrol preferentially inhibits the growth of leukemia cells in culture. Potential mechanisms for its anti-leukemia effect include induction of leukemia cell differentiation, apoptosis, and cell cycle arrest at S-phase; and inhibition of DNA synthesis by inhibiting ribonucleotide reductase or DNA polymerase. Preliminary results suggest that resveratrol also inhibits the viability of freshly isolated leukemia cells, especially promyelocytic leukemia cells. Because of its low in vivo toxicity, resveratrol deserves further investigation as an anti-leukemia agent.
白藜芦醇是一种天然存在于水果、药用植物和葡萄酒中的植保素。它具有多种生物活性。尽管其在适度饮酒人群预防冠心病（CHD）中的作用尚不清楚，但白藜芦醇在体外培养中能优先抑制白血病细胞的生长。其抗白血病作用的潜在机制包括诱导白血病细胞分化、凋亡以及使细胞周期停滞于S期；通过抑制核糖核苷酸还原酶或DNA聚合酶来抑制DNA合成。初步结果表明，白藜芦醇还能抑制新鲜分离的白血病细胞的活力，尤其是早幼粒细胞白血病细胞。由于其体内毒性较低，白藜芦醇作为一种抗白血病药物值得进一步研究。
