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淋病奈瑟菌还原可修饰蛋白的分离与部分特性鉴定

Isolation and partial characterization of the reduction-modifiable protein of Neisseria gonorrhoeae.

作者信息

Lytton E J, Blake M S

出版信息

J Exp Med. 1986 Nov 1;164(5):1749-59. doi: 10.1084/jem.164.5.1749.

DOI:10.1084/jem.164.5.1749
PMID:3095480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188464/
Abstract

We have isolated and purified the reduction-modifiable protein (protein III) from several strains of Neisseria gonorrhoeae. We have found them to be basic proteins (pI 8.6) and virtually identical. A similar but not identical protein was isolated from a meningococcal strain. Antibodies raised against this purified protein would absorb to whole bacteria, confirming that the protein is exposed on the surface of the organism.

摘要

我们已从数株淋病奈瑟菌中分离并纯化出还原可修饰蛋白（蛋白III）。我们发现它们是碱性蛋白（pI 8.6）且几乎完全相同。从一株脑膜炎球菌中分离出了一种类似但不完全相同的蛋白。针对这种纯化蛋白产生的抗体能与完整细菌结合，证实该蛋白暴露于该生物体表面。

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本文引用的文献

1
Studies of Porins: Spontaneously Transferred from Whole Cells and Reconstituted from Purified Proteins of Neisseria gonorrhoeae and Neisseria meningitidis.孔蛋白的研究：从淋病奈瑟菌和脑膜炎奈瑟菌的全细胞中自发转移并由纯化蛋白重构。
Biophys J. 1984 Jan;45(1):104-7. doi: 10.1016/S0006-3495(84)84127-2.
2
125I-peptide mapping of protein III isolated from four strains of Neisseria gonorrhoeae.从四株淋病奈瑟菌中分离出的蛋白质III的125I-肽图谱分析
Infect Immun. 1982 Aug;37(2):622-31. doi: 10.1128/iai.37.2.622-631.1982.
3
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4
One-dimensional peptide mapping of the major outer membrane protein of Neisseria gonorrhoeae.淋病奈瑟菌主要外膜蛋白的一维肽图谱分析
Infect Immun. 1981 Dec;34(3):739-45. doi: 10.1128/iai.34.3.739-745.1981.
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Effects of proteolytic enzymes on the outer membrane proteins of Neisseria gonorrhoeae.蛋白水解酶对淋病奈瑟菌外膜蛋白的影响。
Infect Immun. 1981 Jul;33(1):212-22. doi: 10.1128/iai.33.1.212-222.1981.
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9
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Proc Natl Acad Sci U S A. 1983 Jun;80(12):3831-5. doi: 10.1073/pnas.80.12.3831.
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