State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China; College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China.
Bioorg Chem. 2019 Jun;87:728-735. doi: 10.1016/j.bioorg.2019.03.078. Epub 2019 Apr 1.
Lithocarols A-F (1-6) possessing novel highly-oxygenated isobenzofuran core, together with a related known compound isoprenylisobenzofuran A (7) were isolated from the marine-derived fungus Phomopsis lithocarpus FS508. Among them, lithocarols A-E (1-5) represent the first examples of poly-ketal derivatives in tenellone family. The structures for all these compounds were fully elucidated by spectroscopic analysis, X-ray diffraction, and electronic circular dichroism calculations. Their cytotoxic assay disclosed that compounds 1-4 displayed moderate growth inhibitory effect against four human tumor cell lines with the IC values ranging from 10.5 to 38.7 μM.
从海洋来源的真菌 Phomopsis lithocarpus FS508 中分离得到了 6 个具有新颖高度氧化的异苯并呋喃核心的石碳醇 A-F（1-6），以及一个相关的已知化合物异戊烯基异苯并呋喃 A（7）。其中，石碳醇 A-E（1-5）代表了在 tenellone 家族中首次出现的多酮衍生物。通过光谱分析、X 射线衍射和电子圆二色性计算，充分阐明了所有这些化合物的结构。它们的细胞毒性测定表明，化合物 1-4 对四种人肿瘤细胞系具有中等的生长抑制作用，IC 值范围为 10.5-38.7 μM。
