从海洋来源真菌 FS508 中分离得到的一种新的次生代谢产物。

A new secondary metabolite from the marine-derived fungus FS508.

机构信息

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.

出版信息

J Asian Nat Prod Res. 2024 Apr;26(4):534-540. doi: 10.1080/10286020.2023.2249832. Epub 2023 Aug 28.

DOI:10.1080/10286020.2023.2249832

PMID:37639617

Abstract

Based on the One Strain-Many Compounds (OSMAC) strategy, the secondary metabolites of FS508 were investigated. As a result, a new secondary metabolite, 4-methoxy-3-[4-(acetyloxy)-3-methyl-2-butenyl]benzoic acid () as well as eleven known compounds were isolated from the fermentation product of the strain FS508. Their structures were determined by NMR, IR, UV, and MS spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. Among them, compounds and displayed potent cytotoxicity against HepG-2 cell line, and compounds , and showed significant anti-inflammatory activities.

摘要

基于“一菌多物”（OSMAC）策略，对 FS508 的次级代谢产物进行了研究。结果，从 FS508 菌株的发酵产物中分离得到了一种新的次级代谢产物 4-甲氧基-3-[4-(乙酰氧基)-3-甲基-2-丁烯基]苯甲酸（）以及十一种已知化合物。通过 NMR、IR、UV 和 MS 光谱数据分析确定了它们的结构。所有分离得到的化合物均进行了细胞毒性和抗炎活性评价。其中，化合物和对 HepG-2 细胞系表现出较强的细胞毒性，化合物、和具有显著的抗炎活性。