State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China; School of Chemical and Environmental Engineering, Wuyi University, Jiangmen 529020, China.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Chin J Nat Med. 2021 Nov;19(11):874-880. doi: 10.1016/S1875-5364(21)60095-X.
Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E-I (1-5), and four new benzophenone analogues named tenellones J-M (6-9) were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD calculation and single-crystal X-ray diffraction analysis. The potential anti-tumor activities of compounds 1-9 against four tumor cell lines SF-268, MCF-7, HepG-2, and A549 were evaluated using the SRB method. Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC value of 11.36 μmol·L.
从深海沉积物来源的真菌 Phomopsis lithocarpus FS508 中分离得到了九个新化合物，包括五个天然罕见的 2,3-二氢-1H-茚衍生物，命名为 diaporindenes E-I（1-5），以及四个新的二苯甲酮类似物，命名为 tenellones J-M（6-9）。基于光谱数据、NMR 谱、ECD 计算和单晶 X 射线衍射分析，对所有这些新化合物的结构进行了全面表征。采用 SRB 法评价了化合物 1-9 对 SF-268、MCF-7、HepG-2 和 A549 四种肿瘤细胞系的潜在抗肿瘤活性。化合物 7 对 SF-268 细胞系表现出细胞毒性，IC 值为 11.36 μmol·L。
