长链非编码 RNA ATB 激活的白细胞介素-11 促进食管鳞癌细胞的增殖和侵袭。
IL-11 activated by lnc-ATB promotes cell proliferation and invasion in esophageal squamous cell cancer.
机构信息
Department of Medical Oncology, the First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Cancer Hospital, No. 107 Huanhu East Road, Hefei, 230031, People's Republic of China.
Department of Medical Oncology, the First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Cancer Hospital, No. 107 Huanhu East Road, Hefei, 230031, People's Republic of China; Anhui Medical University, Mei Shan Road, Hefei, 230032, Anhui Province, People's Republic of China.
出版信息
Biomed Pharmacother. 2019 Jun;114:108835. doi: 10.1016/j.biopha.2019.108835. Epub 2019 Apr 4.
IL-11 exerts important functions involved in tumorigenesis and cancer progression. However, the underlying functional role of IL-11 in esophageal squamous cell cancer (ESCC) is not well known. In this paper, we demonstrated that IL-11 expression was increased in esophageal cancer compared with normal tissues, whereas knockdown of IL-11 could inhibit the proliferation and invasion of Eca109 and KYSE410 ESCC cells. Besides, we found that the stability and expression of IL-11 was regulated by lnc-ATB in Eca109 and KYSE410 ESCC cells. More importantly, we found that knockdown of IL-11 partly abolished lnc-ATB-mediated the proliferation and invasion of Eca109 and KYSE410 ESCC cells. Collectively, these results indicated that IL-11 mediated by lnc-ATB increased the proliferation and invasion of ESCC cells, which may provide a promising therapeutic option for suppressing ESCC progression.
IL-11 在肿瘤发生和癌症进展中发挥着重要作用。然而，IL-11 在食管鳞状细胞癌（ESCC）中的潜在功能作用尚不清楚。在本文中，我们证明与正常组织相比，食管癌组织中 IL-11 的表达增加，而敲低 IL-11 可抑制 Eca109 和 KYSE410 ESCC 细胞的增殖和侵袭。此外，我们发现 lnc-ATB 调节 Eca109 和 KYSE410 ESCC 细胞中 IL-11 的稳定性和表达。更重要的是，我们发现敲低 IL-11 部分消除了 lnc-ATB 介导的 Eca109 和 KYSE410 ESCC 细胞的增殖和侵袭。总之，这些结果表明，lnc-ATB 介导的 IL-11 增加了 ESCC 细胞的增殖和侵袭，这可能为抑制 ESCC 进展提供了一种有前途的治疗选择。
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