Division of Allergy, Immunology and Infectious Diseases, Department of Medicine, Rutgers Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 362, New Brunswick, NJ, 08901, USA.
Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, 125 Patterson Street, New Brunswick, NJ, 08901, USA.
Infection. 2019 Aug;47(4):629-635. doi: 10.1007/s15010-019-01304-7. Epub 2019 Apr 6.
Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) is a major cause of morbidity and mortality in hospitalized patients. Ceftaroline fosamil (CPT) is the only available beta-lactam antibiotic with in vitro and in vivo activities against MRSA. There is currently limited clinical experience with CPT in complicated MRSA BSI.
We report a series of eight patients, including three whose strains had reduced susceptibility to vancomycin.
CPT monotherapy was successfully used as salvage therapy for complicated MRSA BSI. The median time to documented clearance was 7 days.
Ceftaroline monotherapy is effective for clearance of refractory MRSA BSI related to implanted devices, endocarditis, and orthopedic infections.
耐甲氧西林金黄色葡萄球菌（MRSA）血流感染（BSI）是住院患者发病率和死亡率的主要原因。头孢洛林酯（CPT）是唯一具有针对 MRSA 的体外和体内活性的β-内酰胺抗生素。目前，CPT 在复杂的 MRSA BSI 中的临床经验有限。
我们报告了一系列 8 例患者，其中 3 例的菌株对万古霉素的敏感性降低。
CPT 单药治疗成功用作复杂的 MRSA BSI 的挽救治疗。有记录的清除中位时间为 7 天。
头孢洛林酯单药治疗可有效清除与植入物、心内膜炎和骨科感染相关的难治性 MRSA BSI。
