Wang Zhuo, Wu Lingling, Fang Qi, Shen Meifen, Zhang Lulu, Liu Xueyun
School of Nursing, Medical College of Soochow University, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Rehabilitation, Yancheng City No.1 People's Hospital, Yancheng, Jiangsu, China.
J Stroke Cerebrovasc Dis. 2019 Jun;28(6):1744-1751. doi: 10.1016/j.jstrokecerebrovasdis.2019.02.008. Epub 2019 Apr 5.
BACKGROUND/AIMS: Dysphagia is a common complication after acute stroke. While there are several innovative treatments being tested to improve the swallowing function of stroke patients with dysphagia, our aim is to explore the use of readily available natural capsaicin in stroke patients with dysphagia.
A randomized, double-blind study.
Sixty-nine hospitalized stroke patients were enrolled in this study. The capsaicin intervention group received thermal tactile stimulation with supplementation of natural capsaicin and additional nectar viscosity boluses. The control group received stimulation and boluses with placebo. Swallowing function was evaluated before and after the 3-week treatment, using Volume-Viscosity Swallow Test, Eating Assessment Tool, Standardized Swallowing Assessment, and Water Swallow Test.
The score decreases in the Eating Assessment Tool and Standardized Swallowing Assessment of the capsaicin intervention group were significantly greater than that of the placebo control group (P < .01). Among the 60 patients, the capsaicin intervention group exhibited effectiveness in a higher number of patients (n = 27, 90%) than the placebo group (n = 9, 30%, P < .001).
Regular use of natural capsaicin could promote the recovery of swallow function in stroke patients with dysphagia. The ample availability of natural capsaicin could provide a low cost, easily accessible, and safe alternative method to address dysphagia in stoke patients.
背景/目的：吞咽困难是急性中风后的常见并发症。虽然有几种创新疗法正在进行测试，以改善吞咽困难的中风患者的吞咽功能，但我们的目的是探索在吞咽困难的中风患者中使用现成的天然辣椒素。
一项随机双盲研究。
69名住院中风患者参与了本研究。辣椒素干预组接受热触觉刺激，并补充天然辣椒素和额外的花蜜粘度食团。对照组接受刺激和使用安慰剂的食团。在为期3周的治疗前后，使用容量-粘度吞咽测试、进食评估工具、标准化吞咽评估和水吞咽测试对吞咽功能进行评估。
辣椒素干预组的进食评估工具和标准化吞咽评估中的得分下降幅度显著大于安慰剂对照组（P <.01）。在60名患者中，辣椒素干预组表现出有效的患者数量（n = 27，90%）高于安慰剂组（n = 9，30%，P <.001）。
定期使用天然辣椒素可促进吞咽困难的中风患者吞咽功能的恢复。天然辣椒素的充足供应可为解决中风患者的吞咽困难提供一种低成本、易于获得且安全的替代方法。
