复发性扁桃体炎 Tfh 细胞获得杀伤性表型。
Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity.
机构信息
Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
出版信息
Trends Immunol. 2019 May;40(5):377-379. doi: 10.1016/j.it.2019.03.007. Epub 2019 Apr 4.
Abstract
Group A Streptococcus (GAS) infection causes recurrent tonsillitis (RT) in some individuals. A recent study (Dan et al. Sci. Transl. Med. 2019;11:eaau3776) demonstrates that RT is associated with an impaired antibody response against a key streptococcal virulence factor. This factor, SpeA, can induce abnormal T follicular helper (Tfh) cells that are able to kill B cells.
摘要
A 组链球菌（GAS）感染可导致某些个体反复发生扁桃体炎（RT）。最近的一项研究（Dan 等人，《科学转化医学》2019；11：eaau3776）表明，RT 与针对关键链球菌毒力因子的抗体反应受损有关。该因子 SpeA 可诱导能够杀死 B 细胞的异常滤泡辅助 T 细胞（Tfh）。
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