Department of Dermatology, Johns Hopkins University School of Medicine, 1800 Orleans St, Baltimore, MD 21287.
Department of Dermatology, Johns Hopkins University School of Medicine, 1800 Orleans St, Baltimore, MD 21287.
J Vasc Interv Radiol. 2019 Sep;30(9):1438-1442. doi: 10.1016/j.jvir.2018.10.007. Epub 2019 Apr 5.
The present report documents 6 patients who developed distinctive hyperpigmented skin lesions after bleomycin sclerotherapy for vascular malformations of the face, neck, and extremities. The patients ranged in age from 2 to 65 years and included both black and white and male and female patients. The bleomycin treatment dose varied from 15 to 45 U, with 5 of the 6 patients receiving foamed bleomycin. The hyperpigmented lesions were near the patient's vascular anomaly and attributable to postprocedural cutaneous pressure (eg, electrocardiographic [ECG] leads or tape). Hyperpigmentation faded slowly over time but was visible up to 3 years after the procedure.
本报告记录了 6 例患者在接受平阳霉素硬化治疗面部、颈部和四肢血管畸形后出现特征性色素沉着皮损。患者年龄 2 至 65 岁，包括黑人和白人以及男性和女性患者。平阳霉素的治疗剂量从 15 至 45 U 不等，其中 5 例患者接受了泡沫型平阳霉素治疗。色素沉着位于患者血管畸形附近，归因于术后皮肤压力（例如心电图 [ECG] 导联或胶带）。色素沉着随时间缓慢消退，但在手术后 3 年内仍可见。
