Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Division of Pediatric Otolaryngology, Arkansas Children's Hospital, Little Rock, AR, USA.
Pediatr Dermatol. 2022 Jan;39(1):103-106. doi: 10.1111/pde.14869. Epub 2021 Dec 12.
Systemic bleomycin therapy is associated with pulmonary fibrosis and cutaneous side effects. While it is believed that there is little to no systemic distribution of bleomycin when utilized to treat vascular malformations (VMs), we present a case series in which cutaneous, adhesive-related hyperpigmentation suggests that there is systemic egress of bleomycin following direct puncture sclerotherapy (DPS). This risk of hyperpigmentation after intralesional bleomycin should be discussed with patients, and steps to minimize the chances of it occurring should be implemented.
全身博来霉素治疗与肺纤维化和皮肤副作用有关。虽然人们认为在治疗血管畸形（VMs）时，博来霉素几乎没有全身分布，但我们提出了一系列病例，其中皮肤、粘连相关的色素沉着表明，在直接穿刺硬化治疗（DPS）后，博来霉素有全身排出。对于腔内博来霉素治疗后发生的这种色素沉着风险，应与患者进行讨论，并应采取措施尽量减少其发生的可能性。
