妊娠早期肝内胆汁淤积症：补充孕酮是罪魁祸首吗？
Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For?
作者信息
Maiskar Vinaya, Surve Sushama
机构信息
Deenanath Mangeshkar Hospital and Research Centre, Pune, 411004 India.
出版信息
J Obstet Gynaecol India. 2019 Apr;69(2):192-193. doi: 10.1007/s13224-018-1174-9. Epub 2018 Sep 11.
Abstract
Progesterone supplementation is a routine practice after intrauterine insemination and IVF-ET procedures. Progesterone is indicated in patients of PCOS and cervical incompetence. It also helps in prevention of recurrent unexplained miscarriages. Effect of a high dose of progesterone supplementation in causing earlier onset of Intrahepatic cholestasis of pregnancy (ICP) merits further focussed investigation.
摘要
宫内授精和体外受精-胚胎移植术后补充孕酮是一种常规做法。多囊卵巢综合征患者和宫颈机能不全患者需要补充孕酮。它还有助于预防原因不明的复发性流产。高剂量补充孕酮导致妊娠肝内胆汁淤积症（ICP）提前发作的影响值得进一步深入研究。
相似文献
1
Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For?妊娠早期肝内胆汁淤积症：补充孕酮是罪魁祸首吗？
J Obstet Gynaecol India. 2019 Apr;69(2):192-193. doi: 10.1007/s13224-018-1174-9. Epub 2018 Sep 11.
2
Progesterone metabolites and bile acids in serum of patients with intrahepatic cholestasis of pregnancy: effect of ursodeoxycholic acid therapy.妊娠肝内胆汁淤积症患者血清中的孕酮代谢物和胆汁酸：熊去氧胆酸治疗的效果
Hepatology. 1997 Dec;26(6):1573-9. doi: 10.1002/hep.510260627.
3
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.妊娠期肝内胆汁淤积症中的胆汁酸和孕酮代谢产物
Ann Med. 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758.
4
Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine.妊娠期肝内胆汁淤积症：熊去氧胆酸改善瘙痒与尿中硫酸脱氢表雄酮减少有关。
Hepatology. 2008 Feb;47(2):544-51. doi: 10.1002/hep.21987.
5
Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term.足月产妇胆汁淤积对人及大鼠胎盘 TGR5 表达的影响。
Placenta. 2013 Sep;34(9):810-6. doi: 10.1016/j.placenta.2013.06.302. Epub 2013 Jul 10.
6
Corticotropin-releasing hormone expression in patients with intrahepatic cholestasis of pregnancy after ursodeoxycholic acid treatment: an initial experience.熊去氧胆酸治疗后妊娠肝内胆汁淤积症患者促肾上腺皮质激素释放激素的表达：初步经验
Curr Med Res Opin. 2014 Aug;30(8):1529-35. doi: 10.1185/03007995.2014.907560. Epub 2014 May 12.
7
Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy.熊去氧胆酸对妊娠肝内胆汁淤积症患者血清和尿液中结合胆汁酸及孕酮代谢产物的影响。
J Hepatol. 1997 Dec;27(6):1029-40. doi: 10.1016/s0168-8278(97)80147-x.
8
9
10
The effects of ursodeoxycholic acid treatment for intrahepatic cholestasis of pregnancy on maternal and fetal outcomes: a meta-analysis including non-randomized studies.熊去氧胆酸治疗妊娠期肝内胆汁淤积症对母婴结局的影响：一项纳入非随机研究的荟萃分析
J Obstet Gynaecol Can. 2014 Jul;36(7):632-641. doi: 10.1016/S1701-2163(15)30544-2.
引用本文的文献
1
Acute liver injury in pregnancy.妊娠急性肝损伤。
BMJ Case Rep. 2024 Feb 21;17(2):e257138. doi: 10.1136/bcr-2023-257138.
本文引用的文献
1
Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic review and meta-analysis of randomized, controlled trials.孕早期补充孕激素以预防不明原因复发性流产妇女的流产：一项随机对照试验的系统评价和荟萃分析
Fertil Steril. 2017 Feb;107(2):430-438.e3. doi: 10.1016/j.fertnstert.2016.10.031. Epub 2016 Nov 22.
2
Co-morbidity of cervical incompetence with polycystic ovarian syndrome (PCOS) negatively impacts prognosis: A retrospective analysis of 178 patients.宫颈机能不全与多囊卵巢综合征（PCOS）的共病对预后有负面影响：178例患者的回顾性分析。
BMC Pregnancy Childbirth. 2016 Oct 12;16(1):308. doi: 10.1186/s12884-016-1094-6.
3
The role of steroid hormones in the development of intrahepatic cholestasis of pregnancy.类固醇激素在妊娠期肝内胆汁淤积症发生发展中的作用。
Physiol Res. 2015;64(Suppl 2):S203-9. doi: 10.33549/physiolres.933117.
4
Intra-hepatic Cholestasis of Pregnancy: A Comprehensive Review.妊娠期肝内胆汁淤积症：综述
Indian J Dermatol. 2013 Jul;58(4):327. doi: 10.4103/0019-5154.113971.
5
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype.妊娠肝内胆汁淤积症中硫酸孕烯醇酮代谢物的水平抑制法尼醇 X 受体，导致胆汁淤积表型。
Hepatology. 2013 Feb;57(2):716-26. doi: 10.1002/hep.26055. Epub 2013 Jan 8.
Zotero 插件