Whitt Michael D, Jackson Mark J
1College of Engineering, California Polytechnic State University, San Luis Obispo, CA 93407 USA.
2School of Integrated Studies, Kansas State University, Polytechnic Campus, Salina, KS 67401 USA.
Biomed Eng Lett. 2018 Nov 30;9(1):87-95. doi: 10.1007/s13534-018-0089-9. eCollection 2019 Feb.
The measurement of endothelial dysfunction (ED) has importance in that it indicates the presence of coronary artery disease (Kuvin et al. in J Am Coll Cardiol 38(7):1843-1849, 2001) in addition to acting as a predictor of future adverse events (Halcox et al. in Circulation 106:653-658, 2002). Various tools, methods, and metrics exist that can provide an indicator of endothelial dysfunction. Given the significance of ED, it is of utmost importance to find a measurement technique that is reliable, while defining a metric providing a framework for an overall system that is practical, accurate, and repeatable. Success would provide a tool for the early detection of cardiovascular disease not only moving patients that are currently classified as asymptomatic to symptomatic, but also providing a method to monitor the efficacy of treatments.
内皮功能障碍（ED）的测量具有重要意义，因为它不仅可作为未来不良事件的预测指标（哈尔考克斯等人，《循环》，第106卷：653 - 658页，2002年），还能表明冠状动脉疾病的存在（库文等人，《美国心脏病学会杂志》，第38卷第7期：1843 - 1849页，2001年）。现有多种工具、方法和指标可用于提供内皮功能障碍的指标。鉴于ED的重要性，找到一种可靠的测量技术至关重要，同时要定义一个指标，为一个实用、准确且可重复的整体系统提供框架。成功将提供一种早期检测心血管疾病的工具，不仅能将目前分类为无症状的患者转变为有症状患者，还能提供一种监测治疗效果的方法。
