Ruggiero Donatella, Savarese Gianluigi, Formisano Roberto, Bologna Ada, Mattiello Giacomo, Pirozzi Elisabetta, Gambardella Francesco, Lo Iudice Francesco, Petraglia Laura, Vitagliano Alice, Casaretti Laura, Della Ratta Giuseppe Luca, Mosca Susanna, Filardi Pasquale Perrone
Dipartimento di Medicina Interna, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II.
Monaldi Arch Chest Dis. 2012 Mar;78(1):34-9. doi: 10.4081/monaldi.2012.142.
to evaluate endothelial function (EF) in diabetic and non-diabetic patients without CAD by peripheral artery tonometry (PAT) technique.
a cohort of 94 patients (55 men and 39 postmenopausal women; mean age 63 +/- 9 years) undergoing coronary angiography was divided into 2 groups: 58 patients with DM and (group 1) and 36 patients without DM. Endothelial dysfunction (ED) was assessed by digital pulse amplitude, using a fingertip peripheral arterial tonometry (PAT). As a measure of ED, reactive hyperemia index (RHI) was calculated as the ratio of the digital pulse volume during reactive hyperemia following 5 min ischemia and its basal value.
prevalence of cardiovascular risk factors was similar between the two groups. RHI values were significantly lower in diabetic patients compared to non-diabetics (1.72 +/- 0.34 vs 2.00 +/- 0.44; p < 0.005) and they correlated with levels of glycosylated hemoglobin (p = 0.05; r = -0.266).
despite similar level of other risk factors, EF was much more impaired in diabetic patients than in non-diabetics. These evidences further support the impact of DM on cardiovascular risk.
通过外周动脉张力测定（PAT）技术评估无冠心病的糖尿病患者和非糖尿病患者的内皮功能（EF）。
对94例接受冠状动脉造影的患者（55例男性和39例绝经后女性；平均年龄63±9岁）进行分组：58例糖尿病患者（第1组）和36例非糖尿病患者。使用指尖外周动脉张力测定仪（PAT）通过数字脉搏振幅评估内皮功能障碍（ED）。作为ED的一项指标，反应性充血指数（RHI）计算为5分钟缺血后反应性充血期间的数字脉搏容积与其基础值之比。
两组心血管危险因素的患病率相似。与非糖尿病患者相比，糖尿病患者的RHI值显著更低（1.72±0.34对2.00±0.44；p<0.005），且它们与糖化血红蛋白水平相关（p = 0.05；r = -0.266）。
尽管其他危险因素水平相似，但糖尿病患者的EF较非糖尿病患者受损更严重。这些证据进一步支持糖尿病对心血管风险的影响。
