Morrison Shannon A, Fazeli Pariya L, Gower Barbara, Younger Jarred, Willig Amanda, Sneed N Markie, Vance David E
Associate Professor, School of Nursing, University of Alabama at Birmingham, USA.
Assistant Professor, School of Nursing, University of Alabama at Birmingham, USA.
J Psychiatry Behav Sci. 2018;3. Epub 2018 Nov 6.
Mitochondrial dysfunction is associated with abnormal glucose metabolism, inflammation and greater oxidative stress in the brain, each of which may contribute uniquely and perhaps synergistically to HIV-Associated Neurocognitive Disorders (HAND) risk. The ketogenic (i.e., low carbohydrate) diet provides the brain with a highly efficient mitochondrial fuel and is associated with improved cognitive performance in older adults with impaired neurocognitive functioning secondary to ageing, Alzheimer's, and Parkinson's disease; however, whether these cognitive gains are generalizable to older adults with HAND is unknown. Thus, the process and cognitive outcomes of the first participant randomized to the intervention and to the control group were investigated in this case-comparison study. To our knowledge, this is first report to establish the plausibility of the ketogenic diet as a treatment for HAND.
线粒体功能障碍与异常的葡萄糖代谢、炎症以及大脑中更大的氧化应激相关，其中每一项都可能独特地甚至协同地导致与HIV相关的神经认知障碍（HAND）风险。生酮（即低碳水化合物）饮食为大脑提供了一种高效的线粒体燃料，并且与患有因衰老、阿尔茨海默病和帕金森病导致神经认知功能受损的老年人的认知表现改善有关；然而，这些认知改善是否适用于患有HAND的老年人尚不清楚。因此，在这项病例对照研究中，对随机分配到干预组和对照组的首位参与者的过程和认知结果进行了调查。据我们所知，这是第一份证实生酮饮食作为HAND治疗方法合理性的报告。
