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生酮饮食对帕金森病症状、生物标志物、抑郁、焦虑和生活质量的影响:一项纵向研究。

Impact of a keto diet on symptoms of Parkinson's disease, biomarkers, depression, anxiety and quality of life: a longitudinal study.

机构信息

College of Graduate Health Studies, A.T. Still University, 800 W. Jefferson Street, Kirksville, MO 63501, USA.

Doctor of Health Science Program, School of Health Sciences, Liberty University, 1971 University Blvd Lynchburg, VA 24515, USA.

出版信息

Neurodegener Dis Manag. 2024;14(3-4):97-110. doi: 10.1080/17582024.2024.2352394. Epub 2024 Jun 13.


DOI:10.1080/17582024.2024.2352394
PMID:38869924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11457624/
Abstract

Evidence suggests low-carbohydrate diets (LCHF) may assist in treating neurodegenerative diseases such as Parkinson's disease (PD); however, gaps exist in the literature. We conducted a small 24-week pilot study to investigate the effects of an LCHF diet on motor and nonmotor symptoms, health biomarkers, anxiety, and depression in seven people with PD. We also captured patient experiences during the process (quality of life [QoL]). Participants reported improved biomarkers, enhanced cognition, mood, motor and nonmotor symptoms, and reduced pain and anxiety. Participants felt improvements enhanced their QoL. We conclude that an LCHF intervention is safe, feasible, and potentially effective in mitigating the symptoms of this disorder. However, more extensive randomized controlled studies are needed to create generalizable recommendations.

摘要

证据表明,低碳水化合物饮食(LCHF)可能有助于治疗帕金森病(PD)等神经退行性疾病;然而,文献中存在空白。我们进行了一项为期 24 周的小型试点研究,以调查 LCHF 饮食对 7 名 PD 患者的运动和非运动症状、健康生物标志物、焦虑和抑郁的影响。我们还在研究过程中记录了患者的体验(生活质量[QoL])。参与者报告说,生物标志物得到改善,认知、情绪、运动和非运动症状得到改善,疼痛和焦虑减轻。参与者认为改善提高了他们的生活质量。我们得出结论,LCHF 干预是安全、可行的,并且可能有效减轻这种疾病的症状。然而,需要进行更广泛的随机对照研究,以制定普遍适用的建议。

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Ketogenic Metabolism in Neurodegenerative Diseases: Mechanisms of Action and Therapeutic Potential.

Metabolites. 2025-7-31

[2]
A mixed methods feasibility study of a ketogenic diet as treatment for Parkinson's disease.

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[3]
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[4]
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Transl Neurodegener. 2025-4-3

[5]
Metabolomics in Parkinson's Disease and Correlation with Disease State.

Metabolites. 2025-3-18

[6]
Impact of the Ketogenic Diet on Neurological Diseases: A Review.

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[7]
The Impact of Diet on Parkinson's Disease: A Systematic Review.

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[8]
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Elife. 2024-10-18

[9]
The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania.

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本文引用的文献

[1]
A comprehensive examination of the evidence for whole of diet patterns in Parkinson's disease: a scoping review.

Nutr Neurosci. 2024-6

[2]
Ketogenic interventions in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease: A systematic review and critical appraisal.

Front Neurol. 2023-2-9

[3]
Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: A randomized, double-blind, placebo-controlled, crossover study, with an open-label extension.

Alzheimers Dement (N Y). 2022-3-14

[4]
Effects of an low carbohydrate/healthy fat/ketogenic diet on biomarkers of health and symptoms, anxiety and depression in Parkinson's disease: a pilot study.

Neurodegener Dis Manag. 2022-4

[5]
Can Ketogenic Diet Improve Alzheimer's Disease? Association With Anxiety, Depression, and Glutamate System.

Front Nutr. 2021-10-27

[6]
Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial.

Clin Park Relat Disord. 2019-8-6

[7]
Progression of Metabolic Syndrome Components along with Depression Symptoms and High Sensitivity C-Reactive Protein: The Bogalusa Heart Study.

Int J Environ Res Public Health. 2021-5-9

[8]
The meaning of postpartum sexual health for women living in Spain: a phenomenological inquiry.

BMC Pregnancy Childbirth. 2021-1-28

[9]
Ketogenic diet and cognition in neurological diseases: a systematic review.

Nutr Rev. 2021-6-4

[10]
Diet Quality and Risk of Parkinson's Disease: A Prospective Study and Meta-Analysis.

J Parkinsons Dis. 2021

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