College of Graduate Health Studies, A.T. Still University, 800 W. Jefferson Street, Kirksville, MO 63501, USA.
Doctor of Health Science Program, School of Health Sciences, Liberty University, 1971 University Blvd Lynchburg, VA 24515, USA.
Neurodegener Dis Manag. 2024;14(3-4):97-110. doi: 10.1080/17582024.2024.2352394. Epub 2024 Jun 13.
Evidence suggests low-carbohydrate diets (LCHF) may assist in treating neurodegenerative diseases such as Parkinson's disease (PD); however, gaps exist in the literature. We conducted a small 24-week pilot study to investigate the effects of an LCHF diet on motor and nonmotor symptoms, health biomarkers, anxiety, and depression in seven people with PD. We also captured patient experiences during the process (quality of life [QoL]). Participants reported improved biomarkers, enhanced cognition, mood, motor and nonmotor symptoms, and reduced pain and anxiety. Participants felt improvements enhanced their QoL. We conclude that an LCHF intervention is safe, feasible, and potentially effective in mitigating the symptoms of this disorder. However, more extensive randomized controlled studies are needed to create generalizable recommendations.
证据表明,低碳水化合物饮食(LCHF)可能有助于治疗帕金森病(PD)等神经退行性疾病;然而,文献中存在空白。我们进行了一项为期 24 周的小型试点研究,以调查 LCHF 饮食对 7 名 PD 患者的运动和非运动症状、健康生物标志物、焦虑和抑郁的影响。我们还在研究过程中记录了患者的体验(生活质量[QoL])。参与者报告说,生物标志物得到改善,认知、情绪、运动和非运动症状得到改善,疼痛和焦虑减轻。参与者认为改善提高了他们的生活质量。我们得出结论,LCHF 干预是安全、可行的,并且可能有效减轻这种疾病的症状。然而,需要进行更广泛的随机对照研究,以制定普遍适用的建议。
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