Raszyk J
Vet Med (Praha). 1986 Oct;31(10):609-20.
We examined the skin samples from 23 fattened pigs with papular dermatitis (PD) and from 17 pigs showing no skin lesions; the live weight of the pigs was from 95 to 105 kg and the pigs came from a large fattening house D that is located in the region where the mines are frequent (lignite extraction). It was only in 26% of pigs with PD where the common ectoparasites Haematopinus suis and Sarcoptes scabiei var. suis were found out. The skin lesions were not fluorescent in the light of Wood's lamp. The fungi Aspergillus flavus, A. fumigatus, A. tereus, Chrysosporium, Mucor sp., Scopulariopsis sp. were sporadically isolated from the skin lesions in 39% of pigs with PD. In 65% of pigs with PD Staphylococcus aureus was isolated from the skin lesions, which was not found in pigs without dermal lesions. Staphylococcus epidermidis was isolated in 87% of pigs with PD and 58% of pigs without any skin changes. The skin lesions were virus-free. Increased concentrations of cadmium and mercury were observed in the skin of pigs with PD and in control pigs. The concentration of aflatoxin B1 in the skin of the two groups of pigs did not exceed the level of 5 micrograms X kg-1, in PD pigs it was, however, twice higher than in the clinically healthy pigs. The residues of chlorinated hydrocarbons in the subcutaneous fat were not higher than the certified hygienic levels. Both epidermis and corium are affected by inflammatory lesions. At the beginning, neutrophil infiltration with necrotization of epithelial cells prevails. It is followed by capillary proliferation with angioblast and fibroblast multiplication and straggled lymphoid infiltration. It is necessary to distinguish by differential diagnostics: swine pox, parakeratosis of swine, lesions of impetigo contagiosa suum, pustular dermatitis and scab of swine, and from rarely occurring skin diseases of swine hypotrichosis cystica suis and demodicosis of swine. No conclusions can be drawn explicitly on the etiology and pathogenesis of papular dermatitis in fattened pigs. We must study the potential interactions of negative environmental factors with regulating homeostatic and adaptation mechanisms in fattened pigs.
我们检查了23头患有丘疹性皮炎（PD）的育肥猪以及17头无皮肤病变猪的皮肤样本；这些猪的活重为95至105千克，来自位于煤矿开采频繁地区（褐煤开采）的大型育肥场D。仅在26%患有PD的猪身上发现了常见的体表寄生虫猪血虱和猪疥螨变种。在伍德灯照射下，皮肤病变不发荧光。在39%患有PD的猪的皮肤病变中偶尔分离出黄曲霉、烟曲霉、土曲霉、金孢子菌、毛霉属、帚霉属真菌。在65%患有PD的猪的皮肤病变中分离出金黄色葡萄球菌，而在无皮肤病变的猪中未发现。在87%患有PD的猪和58%无任何皮肤变化的猪中分离出表皮葡萄球菌。皮肤病变未检测到病毒。在患有PD的猪和对照猪的皮肤中均观察到镉和汞浓度升高。两组猪皮肤中黄曲霉毒素B1的浓度均未超过5微克/千克的水平，但患有PD的猪体内该浓度是临床健康猪的两倍。皮下脂肪中氯代烃的残留不高于认证的卫生水平。表皮和真皮均受到炎性病变影响。起初，以中性粒细胞浸润伴上皮细胞坏死为主。随后是毛细血管增生，有成血管细胞和成纤维细胞增殖以及散在的淋巴细胞浸润。有必要通过鉴别诊断区分：猪痘、猪角化不全、猪传染性脓疱病病变、脓疱性皮炎和猪疥癣，以及罕见的猪皮肤疾病猪毛囊囊肿性脱毛症和猪蠕形螨病。关于育肥猪丘疹性皮炎的病因和发病机制无法明确得出结论。我们必须研究负面环境因素与育肥猪体内调节稳态和适应机制之间的潜在相互作用。
