Valle María, Martín Laura, Maestro Alicia, Andrés José M, Pedrosa Rafael
Instituto CINQUIMA and Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Valladolid, Paseo de Belén 7, 47011 Valladolid, Spain.
Polymers (Basel). 2018 Dec 21;11(1):13. doi: 10.3390/polym11010013.
We have prepared different polymeric chiral bifunctional thioureas and squaramides by modification of the very well-known polymers of intrinsic microporosity (PIM), specifically PIM-1 and PIM-CO-1, to be used as recoverable organocatalysts. The installation of the chiral structures into the polymers has been done in two or three steps in high yields. The catalytic activity of the resulting materials has been proved in the stereoselective nitro-Michael addition and in a cascade process, which allows the synthesis of enantioenriched 4H-chromene derivatives. Squaramide and thiourea have been used in six cycles maintaining their activity.
我们通过对广为人知的固有微孔聚合物（PIM），特别是PIM-1和PIM-CO-1进行改性，制备了不同的聚合物手性双功能硫脲和方酰胺，用作可回收的有机催化剂。手性结构已通过两步或三步以高产率安装到聚合物中。所得材料的催化活性已在立体选择性硝基-Michael加成反应和级联反应中得到证明，这使得对映体富集的4H-色烯衍生物的合成成为可能。方酰胺和硫脲已用于六个循环且保持其活性。
