Megrabian A A, Mkhitarian V G, Amadian M G, Badalian G E, Avakian S L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(9):1407-10.
Using clinico-biochemical and EEG examinations, the authors have studied over time 30 epileptic patients who along with anticonvulsants received lithium carbonate orally and vitamin E in injections. Before the administration of the above drugs epileptic patients with a progressive course of the disease showed intensified lipid peroxidation, low levels of total and free cholesterol of erythrocyte membranes, elevated concentrations of vitamin E and a decreased activity of superoxide dismutase (SOD) in the blood. The use of lithium carbonate and vitamin E leads to a considerable decrease in lipid peroxidation, an elevation in the content of total and free cholesterol of red cell membranes and an increased SOD activity in the blood. There was also a considerable improvement in EEG parameters. The above positive changes in paraclinical indices were accompanied by a reduction in the frequency of epileptic attacks and affective calming of patients. The authors believe that the obtained results can be explained by the normalization of the cell membrane permeability and recommend that lithium carbonate and vitamin E be included into the array of anticonvulsive drugs.
通过临床生化和脑电图检查，作者长期研究了30例癫痫患者，这些患者在服用抗惊厥药物的同时口服碳酸锂并注射维生素E。在使用上述药物之前，患有进行性病程的癫痫患者表现出脂质过氧化增强、红细胞膜总胆固醇和游离胆固醇水平降低、血液中维生素E浓度升高以及超氧化物歧化酶（SOD）活性降低。使用碳酸锂和维生素E可导致脂质过氧化显著降低、红细胞膜总胆固醇和游离胆固醇含量升高以及血液中SOD活性增加。脑电图参数也有显著改善。上述副临床指标的积极变化伴随着癫痫发作频率的降低和患者情绪的平静。作者认为，所获得的结果可以通过细胞膜通透性的正常化来解释，并建议将碳酸锂和维生素E纳入抗惊厥药物的范畴。
