新生期胸腺切除可预防BB/W大鼠发生自发性糖尿病。
Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat.
作者信息
Like A A, Kislauskis E, Williams R R, Rossini A A
出版信息
Science. 1982 May 7;216(4546):644-6. doi: 10.1126/science.7041259.
PMID:7041259
Abstract
Complete neonatal thymectomy reduced the frequency of spontaneous diabetes mellitus in BioBreeding/Worcester rats from 27 to 3 percent. Incomplete thymectomy also significantly reduced the frequency of diabetes (to 9 percent). These findings strengthen the hypothesis that thymus-dependent, cell-mediated autoimmune destruction of pancreatic B cells is responsible for the pathogenesis of diabetes in this experimental animal.
摘要
完全性新生期胸腺切除将BioBreeding/Worcester大鼠自发性糖尿病的发生率从27%降至3%。不完全性胸腺切除也显著降低了糖尿病的发生率（降至9%）。这些发现强化了如下假说：在这种实验动物中，胸腺依赖性、细胞介导的胰腺β细胞自身免疫性破坏是糖尿病发病机制的原因。
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