Price L H, Charney D S, Heninger G R
Am J Psychiatry. 1986 Nov;143(11):1387-92. doi: 10.1176/ajp.143.11.1387.
Eighty-four patients with major depression refractory to a controlled antidepressant trial had lithium added to their ongoing treatment. Objective symptom ratings showed highly significant improvement in the sample as a whole. At discharge or after 24 days, 31% of the patients showed a marked response, 25% a partial response. Thus, 56% of patients had a significant positive response, while 44% were nonresponders. This study indicates that response to lithium augmentation may be quite variable and a 3-week trial is necessary to assess full benefit.
84名对对照性抗抑郁试验难治的重度抑郁症患者在持续治疗中加用了锂盐。客观症状评定显示整个样本有非常显著的改善。在出院时或24天后，31%的患者显示出明显反应，25%为部分反应。因此，56%的患者有显著的阳性反应，而44%为无反应者。这项研究表明，对锂盐增效的反应可能差异很大，需要进行为期3周的试验来评估其全部益处。
