Nierenberg A A, Price L H, Charney D S, Heninger G R
Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
J Affect Disord. 1990 Mar;18(3):167-75. doi: 10.1016/0165-0327(90)90033-5.
There have been no systematic follow-up studies of depressed patients with documented refractoriness to antidepressants treated with lithium augmentation. To assess their longitudinal course, 66 (88%) of an original cohort of 75 such patients were followed in a retrospective, naturalistic design for 29.0 +/- SD 15.3 months. At follow-up, 29% had poor, 23% fair, and 48% good outcomes. An acute marked positive response to lithium augmentation predicted a good subsequent course. Acute partial and non-responders had a less benign outcome despite subsequent treatments. These findings indicate that outcomes of patients with documented refractory depression are heterogeneous. There is a suggestion that an acute marked response to lithium augmentation is sustained regardless of the duration of taking lithium, but this must be regarded as speculative.
对于有记录显示对抗抑郁药难治的抑郁症患者采用锂盐增效治疗，目前尚无系统性的随访研究。为评估他们的纵向病程，在一项回顾性、自然主义设计研究中，对最初75例此类患者中的66例（88%）进行了为期29.0±标准差15.3个月的随访。随访时，29%的患者预后差，23%的患者预后中等，48%的患者预后良好。锂盐增效治疗后急性显著阳性反应预示着随后的病程良好。急性部分反应者和无反应者尽管后续进行了治疗，但其预后仍较差。这些发现表明，有记录显示难治性抑郁症患者的预后存在异质性。有迹象表明，无论服用锂盐的时间长短，锂盐增效治疗后的急性显著反应都会持续，但这一点必须视为推测性的。
