Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, Jiangsu, China; Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, Jiangsu, China.
J Nanosci Nanotechnol. 2019 Sep 1;19(9):5375-5387. doi: 10.1166/jnn.2019.16783.
Quantum dots (QDs), as advanced nanotechnology products, have been widely used in the field of biology and biomedicine, due to their superior optical properties. The bio-safety evaluation of QDs therefore becomes more and more important along with a growing number of studies concerning the potential toxicity of QDs in recent years. In this review, applications of cadmium-containing QDs in bio-medicine fields and their toxic effects on different cells, such as liver cells, kidney cells, lung cells, nervous system cells and fibroblast cells, were introduced. The toxicity mechanisms for QDs causing these adverse effects are also summarized in the end, which include increased synthesis of ROS, immune toxicity, toxicity of QDs synthetic materials, cellular calcium homeostasis dysregulation and DNA damage. This review aims to shade light on future toxicology researches on QDs, which is a topic deserving further exploration.
量子点（QDs）作为先进的纳米技术产品，由于其优异的光学特性，已在生物学和生物医学领域得到了广泛的应用。近年来，随着越来越多的关于 QD 潜在毒性的研究，QDs 的生物安全性评价变得越来越重要。在本文综述中，介绍了含镉量子点在生物医学领域的应用及其对不同细胞（如肝细胞、肾细胞、肺细胞、神经细胞和成纤维细胞）的毒性作用。最后还总结了 QD 引起这些不良反应的毒性机制，包括 ROS 合成增加、免疫毒性、QD 合成材料毒性、细胞钙稳态失调和 DNA 损伤。本文旨在为未来的 QD 毒理学研究提供启示，这是一个值得进一步探索的课题。
