上颌骨陈旧性骨折部位的鳞状细胞癌。

Squamous cell carcinoma at sites of old maxillary fractures.

机构信息

Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.

出版信息

Auris Nasus Larynx. 2020 Jun;47(3):477-480. doi: 10.1016/j.anl.2019.03.008. Epub 2019 Apr 5.

DOI:10.1016/j.anl.2019.03.008

PMID:30962015

Abstract

Malignancies have been reported to occasionally arise in scar tissue following injury. One hypothesis involves prolonged overactivation of tissue repair systems due to chronic inflammation and irritation, although the pathogenesis of cancers occurring in scars is not fully understood. We describe here two cases with a history of maxillary fracture at the site where squamous cell carcinoma (SCC) subsequently developed. The first patient developed SCC 7 years after right maxillary fractures resulting from a traffic accident. He underwent chemoradiotherapy (70 Gy in 35 fractions) and maintained complete response (CR) for 10 months. The second patient developed SCC 3 years after sustaining right maxillary fractures in an ice hockey game. Radiotherapy and total maxillectomy were performed, but local recurrence arose and he has since been receiving chemotherapy.

摘要

据报道，在损伤后的疤痕组织中偶尔会出现恶性肿瘤。一种假说涉及由于慢性炎症和刺激导致组织修复系统的长期过度激活，尽管疤痕中发生的癌症的发病机制尚未完全了解。我们在这里描述了两例病史为上颌骨骨折部位随后发生鳞状细胞癌（SCC）的病例。第一例患者在因交通事故导致右侧上颌骨骨折 7 年后发生 SCC。他接受了放化疗（35 次 70Gy），并在 10 个月内保持完全缓解（CR）。第二例患者在冰球比赛中发生右侧上颌骨骨折 3 年后发生 SCC。进行了放疗和全上颌骨切除术，但出现局部复发，此后他一直在接受化疗。