Department of Medicine, Kern Medical-UCLA, Bakersfield, CA, USA.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:2324709621997248. doi: 10.1177/2324709621997248.
Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In this article, we describe 2 unique cases of malignancy, primary prostate carcinoma and serous carcinoma of the ovary, both of which disseminated to sites of prior trauma. We review the available literature, discuss proposed pathophysiology, and highlight the need for further investigations along with increased clinician awareness.
病灶易损区是指体内抵抗能力下降的区域。这是由于先前创伤引起的微环境变化所致，导致易感性增加。因此，感染、炎症过程和恶性肿瘤可能会集中在这个区域。本文描述了 2 例独特的恶性肿瘤病例，分别为原发性前列腺癌和卵巢浆液性癌，两者均播散至先前创伤部位。我们回顾了现有文献，讨论了提出的病理生理学，并强调需要进一步研究以及提高临床医生的认识。
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