癌细胞在压力下茁壮成长。
Cancer Cells Thrive on Stress.
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université Paris Descartes, Paris, France.
Equipe Labellisée par la Ligue Contre le Cancer, Université Paris Descartes, Université Paris Diderot, Université Sorbonne Paris Cité, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
出版信息
Trends Cell Biol. 2019 Jun;29(6):447-449. doi: 10.1016/j.tcb.2019.03.005. Epub 2019 Apr 5.
Glucocorticoids (GCs) are widely used for the management of disease- or therapy-related complications in cancer patients. Recent data indicate that activation of GC receptors (GRs) precipitates breast cancer progression by favoring metastatic dissemination and cell survival at distant sites. These findings call for the re-evaluation of GC usage in patients with cancer.
糖皮质激素（GCs）被广泛用于治疗癌症患者的疾病或治疗相关并发症。最近的数据表明，GC 受体（GRs）的激活通过促进转移扩散和远处部位的细胞存活，促使乳腺癌的进展。这些发现呼吁重新评估癌症患者中 GC 的使用。
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