内源性和外源性糖皮质激素会消除免疫依赖性癌症疗法的疗效。
Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies.
作者信息
Ma Yuting, Yang Heng, Kroemer Guido
机构信息
Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.
出版信息
Oncoimmunology. 2019 Oct 11;9(1):1673635. doi: 10.1080/2162402X.2019.1673635. eCollection 2020.
Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dendritic cells, causing the subversion of cancer therapy-elicited antineoplastic immune responses and subsequent therapeutic failure.
糖皮质激素介导强大的抗炎和免疫抑制作用。精神压力后内源性糖皮质激素水平的慢性升高，以及外源性糖皮质激素的持续治疗，会激活树突状细胞中的一种免疫抑制转录因子TSC22D3，导致癌症治疗引发的抗肿瘤免疫反应遭到破坏，进而导致治疗失败。
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